Psychoneuroendocrinology
Volume 28, Issue 1 , Pages 19-34 , January 2003

Chronic treatment with the antidepressant tianeptine attenuates lipopolysaccharide-induced Fos expression in the rat paraventricular nucleus and HPA axis activation

Received 3 October 2001 ,Revised 15 January 2002 ,Accepted 16 January 2002.

References 

  1. Ando T, Dunn A. Mouse tumor necrosis factor-α increases brain tryptophan concentrations and norepinephrine metabolism while activating the HPA axis in mice. Neuroimmunomodulation. 1999;6:319–329
  2. Barden N. Regulation of corticosteroid receptor gene expression in depression and antidepressant action. J. Psychiatry Neurosci. 1999;24:25–39
  3. Beck CHM, Fibiger HC. Chronic desipramine alters stress-induced behaviors and regional expression of the immediate early gene, c-fos. Pharmacol. Biochem. Behav. 1995;51:331–338
  4. Castanon N, Dulluc J, Le Moal M, Mormède P. Maturation of the behavioral and neuroendocrine differences between the Roman rat lines. Physiol. Behav. 1994;55:775–782
  5. Castanon N, Bluthé RM, Dantzer R. Chronic treatment with the atypical antidepressant tianeptine attenuates sickness behavior induced by peripheral but not central lipopolysaccharide and interleukin-1β in the rat. Psychopharmacology. 2001;154:50–60
  6. Castanon, N., Leonard, B.E., Neveu, P.J., Yirmiya, R., 2002. Effects of antidepressants on cytokine production and actions. Brain Behav. Immun. (in press).
  7. Czéh B, Michaelis T, Watanabe T, Frahm J, de Biurrum G, van Kampen M, et al. Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine. Proc. Natl. Acad. Sci. 2001;98:12796–12801
  8. Conde GL, Renshaw D, Lighman S, Harbuz M. Serotonin depletion does not alter lipopolysaccharide-induced activation of the rat paraventricular nucleus. J. Endocrinol. 1998;156:245–251
  9. Connor TJ, Harkin A, Kelly JP, Leonard BE. Olfactory bulbectomy provokes a suppression of interleukin-1beta and tumor necrosis factor alpha production in response to an in vivo challenge with lipopolysaccharide: effect of chronic desipramine treatment. Neuroimmunomodulation. 2000;7:27–35
  10. Conrad CD, Galea LAM, Kuroda Y, McEwen BS. Chronic stress impairs rat spatial memory on the Y maze and this effect is blocked by tianeptine pretreatment. Behav. Neurosci. 1996;110:1321–1334
  11. Delbende C, Mocaer E, Rettori M, Kamoun A, Vaudry H. Effect of the antidepressant tianeptine on the activity of the hypothalamo–pituitary–adrenal axis. Eur. J. Pharmacol. 1993;8:49s–54s
  12. Delbende C, Tranchand Bunel D, Tarozzo G, Grino M, Oliver C, Mocaer E, et al. Effect of chronic treatment with the antidepressant tianeptine on the hypothalamo–pituitary–adrenal axis. Eur. J. Pharmacol. 1994;251:245–251
  13. Fattaccini C, Bolaños-Jimenez F, Gozlan H, Hamon M. Tianeptine stimulates uptake of 5-hydroxytryptamine in vivo in the rat brain. Neuropharmacology. 1990;29:1–8
  14. Fontanges R, Mimouni J, de Grieve X, Picard J, Pugeat M, Bange C. Effect of tianeptine on neuroendocrine, enzyme and behavioral responses to restraint stress in male rats. Eur. Psychiatry. 1993;8:67s–73s
  15. Guillaume V, Magnan E, Cataldi M, Héry F, Dutour A, Dadoun F, et al. Effect of tianeptine on the hypothalamic control of the corticotropic response to stress. Eur. J. Psychiatry. 1993;8:55s–60s
  16. Jacobs BL, Praag H, Gage FH. Adult brain neurogenesis and psychiatry: a novel theory of depression. Mol. Psychiatry. 2000;5:262–269
  17. Kato G, Weitsch AF. Neurochemical profile of tianeptine, a new antidepressant drug. Clin. Neuropharmacol. 1988;11:S43–S50
  18. Kelly JP, Leonard BE. The effect of tianeptine and sertraline in three animal models of depression. Neuropharmacology. 1994;33:1011–1016
  19. Konsman JP, Kelley KW, Dantzer R. Temporal and spatial relationships between lipopolysaccharide-induced expression of Fos, interleukin-1β and inducible nitric oxide synthase in the rat brain. Neuroscience. 1999;89:535–548
  20. Kubera M, Simbirtsev A, Mathison R, Maes M. Effects of repeated fluoxetine and citalopram administration on cytokine release in C57BL/6 mice. Psychiatry Res. 2000;96:255–266
  21. Kubera M, Lin A, Kenis G, Bosmans E, Van Bockstaele D, Maes M. Anti-inflammatory effects of antidepressants through suppression of the interferon-γ/interleukin-10 production ratio. J. Clin. Psychopharmacol. 2001;21:199–206
  22. Kubera M, Maes M, Holan V, Basta-Kaim A, Roman A, Shani J. Prolonged desipramine treatment increases the production of interleukin-10, an anti-inflammatory cytokine, in C57BL/6 mice subjected to the chronic mild stress model of depression. J. Affect. Disord. 2001;63:171–178
  23. Laflamme N, Feuvrier E, Richard D, Rivest S. Involvement of serotonergic pathways in mediating the neuronal activity and genetic transcription of neuroendocrine corticotropin-releasing factor in the brain of systemically endotoxin-challenged rats. Neuroscience. 1999;88:223–240
  24. Lin AH, Song C, Kenis G, Bosmans E, De Jongh R, Scharpé S, et al. The in vitro immunosuppressive effects of moclobemide in healthy volunteers. J. Affect. Disord. 2000;58:69–74
  25. Linthorst ACE, Karanth S, Barden N, Holsboer F, Reul JMHM. Impaired glucocorticoid receptor function evolves in aberrant physiological responses to bacterial endotoxin. Eur. J. Neurosci. 1999;11:178–186
  26. López JF, Chalmers DT, Little KY, Watson SJ. Regulation of serotonin1A, glucocorticoid, and mineralocorticoid receptor in rat and human hippocampus: implications for the neurobiology of depression. Biol. Psychiatry. 1998;43:547–573
  27. Maes M. The immunoregulatory effects of antidepressants. Hum. Psychopharmacol. 2001;16:95–103
  28. Maes M, Song C, Lin AH, Bonaccorso S, Kenis G, De Jongh R, et al. Negative immunoregulatory effects of antidepressants: inhibition of interferon-γ and stimulation of interleukin-10 secretion. Neuropsychopharmacology. 1999;20:370–379
  29. Magariños AM, Deslandes A, McEwen BS. Effects of antidepressants and benzodiazepine treatments on the dendritic structure of CA3 pyramidal neurons after chronic stress. Eur. J. Pharmacol. 1999;371:113–122
  30. Malagié I, Deslandes A, Gardier AM. Effects of acute and chronic tianeptine administration on serotonin outflow in rats: comparison with paroxetine by using in vivo microdialysis. Eur. J. Pharmacol. 2000;403:55–65
  31. McEwen BS, Conrad CD, Kuroda Y, Frankfurt M, Magariños AM, McKittrick C. Prevention of stress-induced morphological and cognitive consequences. Eur. Neuropsychopharmacol. 1997;7:S323–S328
  32. Meijer OC, Van Oosten RV, De Kloet ER. Elevated basal trough levels of corticosterone suppress hippocampal 5-hydroxytryptamine(1A) receptor expression in adrenally intact rats: implication for the pathogenesis of depression. Neuroscience. 1997;80:419–426
  33. Murphy BE. Some studies of the protein-binding of steroids and their application to the routine micro and ultramicro measurement of various steroids in body fluids by competitive protein-binding radioassay. J. Clin. Endocrinol. Metab. 1967;27:973–990
  34. Neveu PJ, Castanon N. Is there evidence for an effect of antidepressant drugs on immune function?. Adv. Exp. Med. Biol. 1999;461:267–281
  35. Okugawa G, Omori K, Suzukawa J, Fujiseki Y, Kinoshita T, Inagaki C. Long-term treatment with antidepressants increases glucocorticoid receptor binding and gene expression in cultured rat hippocampal neurones. J. Neuroendocrinol. 1999;11:887–895
  36. Ortiz J, Mariscot C, Alvarez E, Artigas F. Effects of the antidepressant drug tianeptine on plasma and platelet serotonin of depressive patients and healthy controls. J. Affect. Disord. 1993;29:227–234
  37. Piñeyro G, Deveault L, de Montigny C, Blier P. Effect of prolonged administration of tianeptine on 5-HT neurotransmission: an electrophysiological study in the rat hippocampus and dorsal raphe. Naunyn-Schmiedeberg’s Arch. Pharmacol. 1995;351:119–125
  38. Sapolsky RM, Krey LC, McEwen BS. The neuroendocrinology of stress and aging: The glucocorticoid cascade hypothesis. Endocr. Rev. 1986;7:284–301
  39. Shen Y, Connor TJ, Nolan Y, Kelly JP, Leonard BE. Differential effect of chronic antidepressant treatments on lipopolysaccharide-induced depressive-like behavioural symptoms in the rat. Life Sci. 1999;17:1773–1786
  40. Smith EM, Cadet P, Stefano GB, Opp MR, Hughes TK. IL-10 as a mediator in the HPA axis and brain. J. Neuroimmunol. 1999;100:140–148
  41. Suzuki E, Shintani F, Kanba S, Asai M, Nakaki T. Induction of interleukin-1β and interleukin-1 receptor antagonist mRNA by chronic treatment with various psychotropics in widespread area of rat brain. Neurosci. Lett. 1996;215:201–204
  42. Swanson LW, Sawchenko PE. Hypothalamic integration: organization of the paraventricular and supraoptic nuclei. Ann. Rev. Neurosci. 1983;39:33–44
  43. Tuomisto J, Männistö P. Neurotransmitter regulation of anterior pituitary hormones. Pharmacol. Rev. 1985;37:249–332
  44. Turnbull AV, Rivier CL. Regulation of the hypothalamic–pituitary–adrenal axis by cytokines: actions and mechanisms of action. Physiol. Rev. 1999;79:1–71
  45. Wagstaff AJ, Ormrod D, Spencer CM. Tianeptine. A review of its use in depressive disorders. CNS Drugs. 2001;15:231–259
  46. Wan W, Wetmore L, Sorensen CM, Greenberg AH, Nance DM. Neural and biochemical mediators of endotoxin and stress-induced c-fos expression in the rat brain. Brain Res. Bull. 1994;34:7–14
  47. Wilde MI, Benfield P. Tianeptine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depression and coexisting anxiety and depression. Drugs. 1995;49:411–439
  48. Whitton P, Sarna G, Datla K, Curzon G. Effects of tianeptine on stress-induced behavioral deficits and 5-HT dependent behaviour. Psychopharmacology. 1991;104:81–85
  49. Xia Z, De Pierre WJ, Nassberger L. Tricyclic antidepressants inhibit IL-6, IL-1beta and TNF-alpha release in human blood monocytes and IL-2 and interferon-gamma in T cells. Immunopharmacology. 1996;34:27–37
  50. Yirmiya R. Endotoxin produces a depressive-like episode in rats. Brain Res. 1996;711:163–174
  51. Yirmiya R, Pollak Y, Barak O, Avitsur R, Ovadia H, Bette M, et al. Effects of antidepressant drugs on the behavioral and physiological responses to lipopolysaccharide (LPS) in rodents. Neuropsychopharmacology. 2001;24:531–544

PII: S0306-4530(02)00005-7

Psychoneuroendocrinology
Volume 28, Issue 1 , Pages 19-34 , January 2003

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