Psychoneuroendocrinology
Volume 28, Issue 1 , Pages 85-100 , January 2003

Diazepam and progesterone produce sexually dimorphic actions on the rat EEG: role of the neonatal sexual differentiation process

  • A. Fernández-Guasti

      Affiliations

    • Departamento de Farmacobiología, CINVESTAV, Calzada de los Tenorios 235,Col. Granjas Coapa, Mexico City, 14330 D.F., Mexico
    • Corresponding Author InformationCorresponding author. Tel.: +52-54-83-28-56; fax: +52-54-83-28-63
    • ,
  • I.Y. del Río Portilla

      Affiliations

    • Departamento de Psicologia, UNAM, Mexico City, Mexico
    • ,
  • E. Ugalde

      Affiliations

    • Departamento de Psicologia, UNAM, Mexico City, Mexico
    • ,
  • M. Corsi-Cabrera

      Affiliations

    • Departamento de Psicologia, UNAM, Mexico City, Mexico

Received 25 October 2001 ,Revised 24 January 2002 ,Accepted 30 January 2002.

References 

  1. Bitran D, Dowd JA. Ovarian steroids modify the behavioural and neurochemical responses of the central benzodiazepine receptor. Psychopharmacology (Berl.). 1996;125:67–73
  2. Bitran D, Hilvers RJ, Kellogg CK. Anxiolytic effects of 3(-hydroxy-5((β)-pregnan-20-one: endogenous metabolites of progesterone that are active at GABAA receptor. Brain Res. 1991;561:157–161
  3. Bitran D, Purdy RH, Kellogg CK. Anxiolytic effects of progesterone is associated with increase in cortical allopregnanolone and GABAA receptor function. Pharmacol. Biochem. Behav. 1993;45:423–428
  4. Bitran D, Shiekh M, McLeod M. Anxiolytic effect of progesterone is mediated by the neuroesteroid allopregnanolone at brain GABA (A) receptors. J. Neuroendocriol. 1995;7:171–177
  5. Bland HB, Wishaw JK. Generators and topography of hippocampal theta (RSA) in the anaesthetized and freely moving rat. Brain Res. 1976;118:259–280
  6. Brunner DP, Münch M, Biedermann K, Huch R, Huch A, Borbély AA. Changes in sleep and sleep electroencephalogram during pregnancy. Sleep. 1994;17:540–555
  7. Callachan H, Cottrell GA, Hather NY, Lambert JJ, Nooney JM, Peters JA. Modulation of the GABAA receptor by progesterone metabolites. Proc. Roy. Soc. Lond. Brain Biol. Sci.4. 1987;1264:359–369
  8. Corsi-Cabrera M, Juárez J, Ponce-de-León M, Ramos J, Velázquez PN. EEG activity during estral cycle in the rat. Electroenceph. Clin. Neurophysiol. 1992;83:265–269
  9. Corsi-Cabrera M, Pérez-García E, del-Río-Portilla IY, Ugalde E, Guevara MA. EEG during wakefulness, slow wave sleep and paradoxical sleep as a result of principal component analysis in man. Sleep. 2001;24:374–380
  10. Corsi-Cabrera M, Ugalde E, del-Río-Portilla IY, Fernández-Guasti A. Organizational and activational effects of gonadal steroid hormones on the EEG of male and female rats. Dev. Psychobiol. 2000;37:194–207
  11. Coenen AML, van Luijtelaar ELJM. Pharmacological dissociation of EEG and behavior: a basic problem in sleep-wake classification. Sleep. 1991;14:464–465
  12. Coult JT. Neural correlates of attention and arousal from electrophysiology, functional neuroimaging and psychopharmacology. Prog. Neurobiol. 1998;55:343–361
  13. Crawley JN, Glowa JR, Majewska MD, Paul SM. Anxiolytic activity of an endogenous adrenal steroid. Brain Res. 1986;398:382–385
  14. del Río-Portilla IY, Ugalde E, Juárez J, Roldán A, Corsi-Cabrera M. Sex differences in EEG in adult gonadectomized rats before and after hormonal treatment. Psychoneuroendocrinology. 1997;22:627–642
  15. Driver HE, Shapiro CM. A longitudinal study of sleep stages in young women during pregnancy and postpartum. Sleep. 1992;15:449–453
  16. Elliot MA, Becker C, Boucart M, Müller HJ. Enhanced GABAA inhibition enhances synchrony coding in human perception. Cognitive Neurosci. Neurophysiol. 2000;11:3403–3407
  17. Farbollini F, Fluck E, Albonetti E, File SE. Sex differences in benzodiazepine binding in the frontal cortex and amygdala of the rat 24 hours after restraint stress. Neurosci. Lett. 1996;218:177–180
  18. Fernández-Guasti A, Picazo O. The actions of diazepam and serotonergic anxiolytics vary according to the gender and the estrous cycle phase. Pharmacol. Biochem.Behav. 1990;37:77–81
  19. Fernández-Guasti A, Picazo O. Changes in burying behavior during the estrous cycle: effect of estrogen and progesterone. Psychoneuroendocrinology. 1992;17:681–689
  20. Fernández-Guasti A, Picazo O. Flumazenil blocks the anxiolytic actions of allopregnanolone. Eur. J. Pharmacol. 1995;281:113–115
  21. Fernández-Guasti A, Picazo O. Anxiolytic actions of diazepam, but not buspirone, are influenced by gender and the endocrine stage.. Behav. Brain Res. 1997;88:213–218
  22. Fernández-Guasti A, Picazo O. Sexual differentiation modifies the allopregnanolone anxiolytic actions in rats. Psychoneuroendocrinology. 1999;24:251–267
  23. Forgie ML, Stewart J. Sex differences in amphetamine-induced locomotor activity in adult rats. Role of testosterone exposure in the neonatal period. Pharmacol. Biochem. Behav. 1993;46:637–645
  24. Friess E, Tagaya H, Trachsel L, Holsboer F, Rupprecht R. Progesterone-induced changes in sleep in male subjects. Am. J. Physiol. 1997;272:E885–E891
  25. Gasser T, Bächer P, Möcks J. Transformation toward the normal distribution of broad band spectral parameters of the EEG. Electroenceph. Clin. Neuphysiol. 1982;53:119–124
  26. Gee KW, Bolger MB, Brinton RE, Coirini H, McEwen BS. Steroid modulation of the chloride ionophore in rat brain: structure–activity requirements, regional dependence and mechanisms of action. J. Pharmacol. Exp. Ther. 1988;246:803–812
  27. Greenblatt DJ, Harmatz JS, Von Moltke LL, Wright E, Durol ALB, Harrel-Joseph LM, et al. Comparative kinetics and response to the benzodiazepine agonists triazolam and zolpidem: evaluation of sex-dependent differences. J. Pharmacol. Exp. Ther. 2000;293:435–443
  28. Guevara MA, Corsi-Cabrera M. EEG correlation or EEG coherence?. Int. J. Psychophysiol. 1996;23:145–153
  29. Gulinello M, Gong QH, Li X, Smith SS. Short-term exposure to a neuroactive steroid increases alpha4 GABA(A) receptor subunit levels in association with increased anxiety in the female rat. Brain Res. 2001;910:55–66
  30. Hawke RL, Welch RM. Major differences in the specificity and regulation of mouse renal cytochrome P-450-dependent monooxygenases. A comparison of xenobiotic and endogenous substrates. Mol. Pharmacol. 1985;28:283–289
  31. Iwata N, Mikuni N. EEG changes in the conscious rat during immobility induced by psychological stress. Psychopharmacology. 1980;71:117–122
  32. John ER, Ahn H, Prichep L, Trepetin M, Brown D, Kaye H. Developmental equations for the EEG. Science. 1980;210:1255–1258
  33. Juárez J, Corsi-Cabrera M. Sex differences in interhemispheric correlation and spectral power of EEG activity. Brain Res. Bull. 1995;38:149–151
  34. Juárez J, Corsi-Cabrera M, del Río-Portilla IY. Effects of prenatal testosterone treatment on sex differences in the EEG activity of the rat. Brain Res. 1995;694:21–28
  35. Kleinlogel H. Analysis of the vigilance stages in the rat by Fast Fourier Transformation. Pharmacoelectroencephalography. 1991;23:197–204
  36. Lancel M, Faulhaber J, Holsboer F, Ruprecht R. Progesterone induces changes in sleep comparable to those of agonistic GABAA receptor modulators. Am. J. Physiol. 1996;271:E763–E772
  37. Lancel M. Role of GABAA receptors in the regulation of sleep: initial sleep responses to peripherally administered modulators and agonists. Sleep. 1999;22:33–44
  38. Lancel M, Faulhaber J, Schiffelholz T, Romeo E, Di Michele F, Holsboer F, et al. Allopregnanolone affects sleep in a benzodiazepine-like fashion. J. Pharmacol. Exp. Ther. 1997;282:1213–1218
  39. Leung SL, Lopes da Silva FH, Wadman WJ. Spectral characteristics of the hippocampal EEG in the freely moving rat. Electroencephalogr. Clin. Neurophysiol. 1982;54:203–219
  40. Majewska MD. Neurosteroids: endogenous bimodal modulators of the GABAA receptor. Mechanisms of action and physiological significance. Progr. Neurobiol. 1992;38:379–395
  41. Majewska MD, Harrison NL, Schwartz RD, Barker JL, Paul SM. Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor. Science. 1986;232:1004–1007
  42. McCarthy MM, Feltzenberg E, Robbins A, Pfaff DW, Schwartz-Giblin S. Infusions of diazepam and allopregnanolone into the midbrain central brain facilitate open field behavior and sexual receptivity in female rats. Horm. Behav. 1995;29:279–295
  43. McCauley LD, Gee KW. Influence of the estrous cycle on the discrimination of apparent neuroactive steroids subtypes on the gamma aminobutyric acid A receptor complex in the rat. J. Pharmacol. Exp. Ther. 1995;175:1412–1417
  44. Melchior CL, Ritzmann RF. Pregnenolone and pregnenolone sulfate alone and with ethanol in mice on the plus maze. Pharmacol. Biochem. Behav. 1994;48:893–897
  45. Norberg L, Backstrom T, Wahlstrom G. Anaesthetic effects of pregnanolone in combination with allopregnanolone, thiopental, hexobarbital and flurazepam: an EEG study in the rat. Br. J. Anaesth. 1999;82:731–737
  46. Núñez PL. Quantitative states of the cortex. In:  Núñez PL editors. Neocortical Dynamics and Human EEG Rhythms. New York: Oxford University Press; 1995;p. 3–67
  47. Peters JA, Kirkness EF, Callachan H. Modulation of the GABAA receptor by depressant barbiturates and pregnane steroids. Br. J. Pharmacol. 1988;94:1257–1269
  48. Petsche H, Stumpf C. Topographic and toposcopic study of origin and spread of the regular synchronized arousal pattern in the rabbit. Electroencephalogr. Clin. Neurophysiol. 1960;12:589–600
  49. Picazo O, Fernández-Guasti A. Anti-anxiety effects of progesterone and some of its reduced metabolites: an evaluation using the burying behavior test. Brain Res. 1995;680:135–141
  50. Reddy DS, Kulkarni SK. Role of GABAA and mitochondrial diazepam binding inhibitor receptors in the anti-stress activity of neurosteroids in mice. Psychopharmacology. 1996;128:280–292
  51. Rodgers RJ, Johnson JT. Behaviourally selective effects of neuroactive steroids on plus maze anxiety in mice. Pharmacol. Biochem. Behav. 1998;59:221–232
  52. Rodríguez-Sierra JF, Hagley MT, Hendricks SE. Anxiolytic effects of progesterone are sexually dimorphic. Life Sci. 1986;38:1841–1845
  53. Rodríguez-Sierra JF, Howard JL, Pollard GT. Effects of ovarian hormones on conflict behavior. Psychoneuroendocrinology. 1984;9:293–300
  54. Rupprecht R. The neuropsychopharmacological potential of neuroactive steroids. J. Psychiat. Res. 1997;31:297–314
  55. Schumacher M. Rapid membrane effects of steroid hormones: an emerging concept in neuroendocrinology. Trends Neurosci. 1990;13:359–362
  56. Shaw JC. Correlation and coherence analysis of the EEG: a selective tutorial review. Intern. J. Psycophysiol. 1984;1:255–266
  57. Solís-Ortiz S, Ramos J, Arce C, Guevara MA, Corsi-Cabrera M. EEG oscillations during menstrual cycle. Intern. J. Neurosci. 1994;76:279–292
  58. Sodersten P. Sexual differentiation: do males differ from females in behavioral sensitivity to gonadal hormones?. Prog. Brain Res. 1984;61:257–270
  59. Squires RF, Braestrup C. Benzodiazepine receptors in rat brain. Nature. 1977;166:732–734
  60. Ugalde E, del-Río-Portilla IY, Juárez J, Roldán A, Guevara MA, Corsi-Cabrera M. Effect of diazepam and sex hormones on EEG of gonadectomized male and female rats. Psychoneuroendocrinology. 1998;23:701–712
  61. van der Wolf CH. The electrocorticogram in relation to physiology and behavior: a new analysis. Electroencephalogr. Clin. Neurophysiol. 1992;82:165–175
  62. Wieland S, Lan NC, Mirasedeghi S, Gee KW. Anxiolytic activity of progesterone metabolite 5-alpha pregnan-3 alpha ol-20 one. Brain Res. 1991;565:263–268
  63. Wieland S, Belluzzi JD, Stein L, Lan NC. Comparative behavioural characterization of the neuroactive steroids 3 alpha-OH, 5 alpha-pregnan-20-one and 3 alpha-OH, 5 beta-pregnan-20-one in rodents. Psychopharmacology. 1995;118:65–71
  64. Winson J. Patterns of hippocampal theta rhythm in the freely moving rat. Electroencephalogr. Clin. Neurophysiol. 1974;36:291–301

PII: S0306-4530(02)00011-2

Psychoneuroendocrinology
Volume 28, Issue 1 , Pages 85-100 , January 2003

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