Psychoneuroendocrinology
Volume 28, Issue 1 , Pages 113-120 , January 2003

Steroid-induced elevation of glucose in Alzheimer’s disease: relationship to gender, apolipoprotein E genotype and cognition

  • P.S Aisen

      Affiliations

    • Department of Neurology, Georgetown University Medical Center, 1Bles Building, 3800 Reservoir Road NW, 20007 Washington, DC, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1-202-687-7337; fax: +1-202-784-4334
    • ,
  • J.D Berg

      Affiliations

    • Alzheimer s Disease Cooperative Study, University of California San Diego, San Diego, CA, USA
    • ,
  • S Craft

      Affiliations

    • Geriatric Research, Education and Clinical Center, Veteran Affairs Puget Sound Health Care System, University of Washington School of Medicine, Seattle, WA, USA
    • Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA
    • ,
  • E.R Peskind

      Affiliations

    • Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA
    • Mental Illness Research, Education and Clinical Center, Veteran Affairs Puget Sound Health Care System, University of Washington School of Medicine, Seattle, WA, USA
    • ,
  • M Sano

      Affiliations

    • Gertrude H. Sergievsky Center, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA
    • ,
  • L Teri

      Affiliations

    • Department of Psychosocial and Community Health, University of Washington School of Medicine, Seattle, WA, USA
    • ,
  • R.A Mulnard

      Affiliations

    • Institute for Brain Aging and Dementia, University of California Irvine, Irvine, CA, USA
    • ,
  • R.G Thomas

      Affiliations

    • Departments of Family and Preventive Medicine, University of California San Diego, San Diego, CA, USA
    • ,
  • L.J Thal

      Affiliations

    • Department of Neurosciences, University of California at San Diego, San Diego, CA, USA

Received 6 December 2001 ,Revised 1 February 2002 ,Accepted 6 February 2002.

References 

  1. Aisen PS, Davis KL, Berg JD, Schafer K, Campbell K, Thomas RG, et al. A randomized controlled trial of prednisone in Alzheimer s disease, Alzheimer s disease cooperative study. Neurology. 2000;54:588–593
  2. Andrews RC, Walker BR. Glucocorticoids and insulin resistance: old hormones, new targets. Clin. Sci. (Colch). 1999;96:513–523
  3. Craft S, Asthana S, Newcomer JW, Wilkinson CW, Matos IT, Baker LD, et al. Enhancement of memory in Alzheimer disease with insulin and somatostatin, but not glucose. Arch. Gen. Psychiatry. 1999;56:1135–1140
  4. Craft S, Asthana S, Schellenberg G, Cherrier M, Baker LD, Newcomer J, et al. Insulin metabolism in Alzheimer s disease differs according to apolipoprotein E genotype and gender. Neuroendocrinology. 1999;70:146–152
  5. Craft S, Dagogo-Jack SE, Wiethop BV, Murphy C, Nevins RT, Fleischman S, et al. Effects of hyperglycemia on memory and hormone levels in dementia of the Alzheimer type: a longitudinal study. Behav. Neurosci. 1993;107:926–940
  6. Craft S, Newcomer J, Kanne S, Dagogo-Jack S, Cryer P, Sheline Y, et al. Memory improvement following induced hyperinsulinemia in Alzheimer s disease. Neurobiol. Aging. 1996;17:123–130
  7. Craft S, Peskind E, Schwartz MW, Schellenberg GD, Raskind M, Porte D. Cerebrospinal fluid and plasma insulin levels in Alzheimer s disease - relationship to severity of dementia and apolipoprotein E genotype. Neurology. 1998;50:164–168
  8. Finch CE, Cohen DM. Aging, metabolism, and Alzheimer disease: review and hypotheses. Exp. Neurol. 1997;143:82–102
  9. Hoyer S. Is sporadic Alzheimer disease the brain type of non-insulin dependent diabetes mellitus? A challenging hypothesis. J. Neural. Transm. 1998;105:415–422
  10. Hoyer S, Blum-Degen D, Bernstein HG, Engelsberger S, Humrich J, Laufer S, et al. Brain insulin and insulin receptors in aging and sporadic Alzheimer s disease. J. Neural. Transm. 1998;105:423–438
  11. Kuusisto J, Koivisto K, Mykkaenen L, Helkala EL, Vanhanen M, Haenninen T, et al. Association between features of the insulin resistance syndrome and Alzheimer s disease independently of apolipoprotein E4 phenotype: cross sectional population based study. Br. Med. J. 1997;315:1045–1049
  12. Manning CA, Ragozzino ME, Gold PE. Glucose enhancement of memory in patients with probable senile dementia of the Alzheimer s type. Neurobiol. Aging. 1993;14:523–528
  13. Meneilly, G.S., Hill, A., 1993. Alterations in glucose metabolism in patients with Alzheimer s disease. J. Am. Geriatr. Soc. 41, 710–714.
  14. Mulnard RA, Cotman CW, Kawas C, van Dyck CH, Sano M, Doody R, et al. Estrogen replacement therapy for treatment of mild to moderate Alzheimer disease: a randomized controlled trial, Alzheimer s disease cooperative study. JAMA. 2000;283:1007–1015
  15. Parsons MW, Gold PE. Glucose enhancement of memory in elderly humans: an inverted-U dose-response curve. Neurobiol. Aging. 1992;13:401–404
  16. Rosen WG, Mohs RC, Davis KL. A new rating scale for Alzheimer s disease. Am. J. Psychiatry. 1984;141:1356–1364
  17. Sano M, Ernesto C, Thomas RG, Klauber MR, Schafer K, Grundman M, et al. A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer s disease. N. Engl. J. Med. 1997;336:1216–1222
  18. Teri L, Logsdon RG, Peskind E, Raskind M, Weiner MF, Tractenberg RE, et al. Treatment of agitation in AD: a randomized, placebo-controlled clinical trial. Neurology. 2000;55:1271–1278

PII: S0306-4530(02)00015-X

Psychoneuroendocrinology
Volume 28, Issue 1 , Pages 113-120 , January 2003

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