Psychoneuroendocrinology
Volume 31, Issue 6 , Pages 681-691 , July 2006

The effects of growth hormone (GH) deficiency and GH replacement on cognitive performance in adults: A meta-analysis of the current literature

  • Marina G. Falleti

      Affiliations

    • CogState Ltd, Level 7, 21 Victoria Street, Melbourne, Vic. 3000, Australia
    • Corresponding Author InformationCorresponding author. Tel.: +61 3 9664 1300; fax: +61 3 9664 1301.
    • ,
  • Paul Maruff

      Affiliations

    • CogState Ltd, Level 7, 21 Victoria Street, Melbourne, Vic. 3000, Australia
    • ,
  • Pia Burman

      Affiliations

    • University Hospital MAS, Malmö, Sweden
    • ,
  • Alan Harris

      Affiliations

    • Departments of Pharmacology and Medicine, New York University Scool of Medicine, New York, USA

Received 2 September 2005 ,Revised 18 January 2006 ,Accepted 19 January 2006.

References 

  1. Almqvist O, Thoren M, Saaf M, Eriksson O. Effects of growth hormone substitution on mental performance in adults with growth hormone deficiency: a pilot study. Psychoneuroendocrinology. 1986;11:347–352
  2. Arwert LI, Deijen JB, Müller M, Drent ML. Long-term growth hormone treatment preserves GH-inducted memory and mood improvements: a 10-year follow-up study in GH-deficient adult men. Horm. Behav. 2005;47:343–349
  3. Arwert LI, Deijen JB, Witlox J, Drent ML. The influence of growth hormone (GH) substitution on patient-reported outcomes and cognitive functions in GH-deficient patients: a meta-analysis. Growth Horm. IGF Res. 2005;15:47–54
  4. Austin MP, Mitchell P, Wilhelm K, Parker G, Hickie I, Brodaty H, et al. Cognitive function in depression: a distinct pattern of frontal impairment in melancholia?. Psychol. Med. 1999;29:73–85
  5. Baum HBA, Katznelson L, Sherman JC, Biller BMK, Hayden DL, Schoenfeld DA, et al. Effects of physiological growth hormone (GH) therapy on cognition and quality of life in patients with adult-onset GH deficiency. J. Clin. Endocrinol. Metab. 1998;83:3184–3189
  6. Bulow B, Hagmar L, Orbaek P, Osterberg K, Erfurth EM. High incidence of mental disorders, reduced mental well-being and cognitive function in hypopituitary women with GH deficiency treated for pituitary disease. Clin. Endocrinol. 2002;56:183–193
  7. Burman P, Deijen JB. Quality of life and cognitive function in patients with pituitary insufficiency. Psychother. Psychosom. 1998;67:154–167
  8. Carroll PV, Christ ER, Bengtsson BA, Carlsson L, Christiansen JS, Clemmons D, et al. Growth hormone deficiency in adulthood and the effects of growth hormone replacement: a review. J. Clin. Endocrinol. Metab. 1998;83:382–395
  9. Cohen J. Statistical Power Analysis for the Behavioural Sciences. second ed.. New York: Academic Press; 1988;
  10. Degerblad M, Almkvist O, Grunditz R, Hall K, Kaijser L, Knutsson E, et al. Physical and psychological capabilities during substitution therapy with recombinant growth hormone in adults with growth hormone deficiency. Acta Endocrinol. 1990;123:185–193
  11. Deijen JB, de Boer H, Blok GJ, van der Veen EA. Cognitive impairments and mood disturbances in growth hormone deficient men. Psychoneuroendocrinology. 1996;21:313–322
  12. Deijen JB, de Boer H, van der Veen EA. Cognitive changes during growth hormone replacement in adult men. Psychoneuroendocrinology. 1998;23:45–55
  13. Dunlap WP, Cortina JM, Vaslow JB, Burke MJ. Meta-analysis of experiments with matched groups or repeated measures designs. Psychol. Methods. 1996;1:170–177
  14. Falleti MG, Sanfilipo A, Maruff P, Weih L, Phillips KA. The nature and severity of cognitive impairment associated with adjuvant chemotherapy in women with breast cancer: a meta-analysis of the current literature. Brain Cogn. 2005;59:60–70
  15. Golgeli A, Tanriverdi F, Suer C, Gokce C, Ozesmi C, Bayram F, et al. Utility of P300 auditory event related potential latency in detecting cognitive dysfunction in growth hormone (GH) deficient patients with sheehan's syndrome and effects of GH replacement therapy. Eur. J. Endocrinol. 2004;150:153–159
  16. Lasaite L, Bunevicius R, Lasiene D, Lasas L. Psychological functioning after growth hormone therapy in adult growth hormone deficient patients: endocrine and body composition correlates. Medicina (Kaunas). 2004;40:740–744
  17. Lezak MD. Neuropsychological assessment. third ed.. New York: Oxford University Press; 1995;
  18. Lijffijt M, van Dam PS, Kenemans JL, Koppeschaar HPF, de Vries WR, Drent ML, et al. Somatotropic-axis deficiency affects brain substrates of selective attention in childhood-onset growth hormone deficient patients. Neurosci. Lett. 2003;353:123–126
  19. Maruf, P., Falleti, M.G., 2005. Congnitive function in growth hormone deficiency and growth hormone replacement. Horm. Res. 64, supplement 3, 100–108.
  20. Maruff P, Currie J, McArthur-Jackson C, Mulhall B, Benson E. Neuropsychological characterisation of the AIDs dementia complex: rationalisaion of test battery. Arch. Neurol. 1994;51:689–695
  21. Oertel H, Schneider HJ, Stalla GK, Holsboer F, Zihl J. The effect of growth hormone substitution on cognitive performance in adult patients with hypopituitarism. Psychoneuroendocrinology. 2004;29:839–850
  22. Pavel ME, Lohmann T, Hahn EG, Hoffman M. Impact of growth hormone on central nervous activity, vigilance, and tiredness after short-term therapy in growth hormone-deficient adults. Horm. Metab. Res. 2003;35:114–119
  23. Peace KA, Orme SM, Padayatty SJ, Godfrey HPD, Belchetz PE. Cognitive dysfunction in patients with pituitary tumour who have been treated with transfrontal or transsphenoidal surgery or medication. Clin. Endocrinol. 1998;49:391–396
  24. Reger M, Welsh R, Razani J, Martin DJ, Boone KB. A meta-analysis of the neuropsychological sequelae of HIV infection. JINS. 2002;8:410–424
  25. Sands SA. Editorial: intelligence and psychosocial functioning during long-term growth hormone therapy in children born small for gestational age. J. Clin. Endocrinol. Metab. 2004;89:5292–5294
  26. Sartorio A, Molinari E, Riva G, Conti A, Morabito F, Faglia G. Growth hormone treatment in adults with childhood onset growth hormone deficiency: effects on psychological capabilities. Horm. Res. 1995;44:6–11
  27. Schretken DJ, Shapiro AM. A quantitative review of the effects of traumatic brain injury on cognitive functioning. Int. Rev. Psychiat. 2003;15:341–349
  28. Stouthart PJHM, Deijen JB, Roffel M, Delemarre-van de Waal HA. Quality of life of growth hormone (GH) deficient young adults during discontinuation and restart of GH therapy. Psychoneuroendocrinology. 2003;28:612–626
  29. Van Dam PS, de Winter CF, de Vries R, van der Grond J, Drent ML, Lijffijt M, et al. Childhood-onset growth hormone deficiency, cognitive function and brain N-acetylaspartate. Psychoneuroendocrinology. 2005;30:357–363
  30. Witte RS. Statistics. seventh ed.. Hoboken, NJ: Wiley; 2004;
  31. Wolf FM. Meta-analysis: quantitative methods for research synthesis. Newbury, London: Sage; 1986;
  32. Zakzanis KK. Statistics to tell the truth, the whole truth, and nothing but the truth: formulae, illustrative numerical examples, and heuristic interpretation of effect size analyses for neuropsychological researchers. Arch. Clin. Neuropsychol. 2001;16:653–667

PII: S0306-4530(06)00007-2

doi: 10.1016/j.psyneuen.2006.01.005

Psychoneuroendocrinology
Volume 31, Issue 6 , Pages 681-691 , July 2006

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