Psychoneuroendocrinology
Volume 31, Issue 6 , Pages 781-785 , July 2006

Corticosterone response to acute stress in a mouse model of Fragile X syndrome

  • Julie A. Markham

      Affiliations

    • Beckman Institute, University of Illinois at Urbana-Champaign, 405 North Mathews Avenue, Urbana, IL 61801, USA
    • Department of Psychology, University of Illinois at Urbana-Champaign, 603 East Daniel Street, Champaign, IL 61820, USA
    • Corresponding Author InformationCorresponding author. Address: Beckman Institute, University of Illinois at Urbana-Champaign, 405 North Mathews Avenue, Urbana, IL 61801, USA. Tel.: +1 217 333 3753; fax: +1 217 244 5180.
    • ,
  • Andrea C. Beckel-Mitchener

      Affiliations

    • Molecular, Cellular, and Genomic Neuroscience Research Branch, Division of Neuroscience and Basic Behavioral Science, National Institute of Mental Health, Neuroscience Center, 6001 Executive Boulevard, Bethesda, MD 20892-9641, USA
    • This work was not written as part of Andrea Beckel-Mitchener's official duties as a Government employee. The views expressed in this article do not necessarily represent the views of the NIMH, NIH, HHS, or the United States Government.
    • ,
  • Christina M. Estrada

      Affiliations

    • Department of Molecular and Cellular Biology, University of Illinois at Urbana-Champaign, 393 Morrill Hall, 505 South Goodwin Avenue, Urbana, IL 61801, USA
    • ,
  • William T. Greenough

      Affiliations

    • Beckman Institute, University of Illinois at Urbana-Champaign, 405 North Mathews Avenue, Urbana, IL 61801, USA
    • Department of Psychology, University of Illinois at Urbana-Champaign, 603 East Daniel Street, Champaign, IL 61820, USA
    • Department of Molecular and Cellular Biology, University of Illinois at Urbana-Champaign, 393 Morrill Hall, 505 South Goodwin Avenue, Urbana, IL 61801, USA
    • Neuroscience Program, University of Illinois at Urbana-Champaign, 318B Morrill Hall, 505 South Goodwin Avenue, Urbana, IL 61801, USA

Received 10 October 2005 ,Revised 23 January 2006 ,Accepted 20 February 2006.

References 

  1. Beckel-Mitchener, A.C., Churchill, J.D., Kim, S., Estrada, C.M., Greenough, W.T., 2003. Prolonged elevation of serum glucocorticoid (corticosterone) levels in Fragile X knockout mice after acute restraint. Proceedings of the Society for Neuroscience, Program No. 646.645.
  2. Crawford DC, Acuna JM, Sherman SL. FMR1 and the fragile X syndrome: human genome epidemiology review. Genet. Med. 2001;3:359–371
  3. Critchlow V, Liebelt RA, Bar-Sela M, Mountcastle W, Lipscomb HS. Sex difference in resting pituitary–adrenal function in the rat. Am. J. Physiol. 1963;205:807–815
  4. de Kloet ER, Oitzl MS, Joels M. Stress and cognition: are corticosteroids good or bad guys?. Trends Neurosci. 1999;22:422–426
  5. Hessl D, Glaser B, Dyer-Friedman J, Blasey C, Hastie T, Gunnar M, et al. Cortisol and behavior in fragile X syndrome. Psychoneuroendocrinology. 2002;27:855–872
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  8. Lauterborn JC. Stress induced changes in cortical and hypothalamic c-fos expression are altered in Fragile X mutant mice. Mol. Brain Res. 2004;131:101–109
  9. Lupien SJ, Fiocco A, Wan N, Maheu F, Lord C, Schramek T, et al. Stress hormones and human memory function across the lifespan. Psychoneuroendocrinology. 2005;30:225–242
  10. Miyashiro KY, Beckel-Mitchener A, Purk TP, Becker KG, Barret T, Liu L, et al. RNA cargoes associating with FMRP reveal deficits in cellular functioning in Fmr1 null mice. Neuron. 2003;37:417–431
  11. Shors TJ. Learning during stressful times. Learn Mem. 2004;11:137–144
  12. Tassone F, Hagerman RJ, Ikle DN, Dyer PN, Lampe M, Willemsen R, et al. FMRP expression as a potential prognostic indicator in fragile X syndrome. Am. J. Med. Genet. 1999;84:250–261
  13. Ventura R, Pascucci T, Catania MV, Musumeci SA, Puglisi-Allegra S. Object recognition impairment in Fmr1 knockout mice is reversed by amphetamine: involvement of dopamine in the medial prefrontal cortex. Behav. Pharmacol. 2004;15:433–442
  14. Wisbeck JM, Huffman LC, Freund L, Gunnar MR, Davis EP, Reiss AL. Cortisol and social stressors in children with fragile X: a pilot study. J. Dev. Behav. Pediatr. 2000;21:278–282
  15. Zhao MG, Toyoda H, Ko SW, Ding HK, Wu LJ, Zhuo M. Deficits in trace fear memory and long-term potentiation in a mouse model for fragile X syndrome. J. Neurosci. 2005;25:7385–7392

PII: S0306-4530(06)00035-7

doi: 10.1016/j.psyneuen.2006.02.008

Psychoneuroendocrinology
Volume 31, Issue 6 , Pages 781-785 , July 2006

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