Psychoneuroendocrinology
Volume 32, Issue 5 , Pages 503-507 , June 2007

Sex differences in ACTH pulsatility following metyrapone blockade in patients with major depression

  • Elizabeth A. Young

      Affiliations

    • Department of Psychiatry, The University of Michigan, Ann Arbor, MI 48109, USA
    • Molecular and Behavioral Neurosciences Institute, The University of Michigan, Ann Arbor, MI 48109, USA
    • Corresponding Author InformationCorresponding author. Molecular and Behavioral Neurosciences Institute, The University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI 48109-0720, USA. Tel.: 17349362087; fax: +17346474130.
    • ,
  • Saulo C. Ribeiro

      Affiliations

    • Department of Psychiatry, The University of Michigan, Ann Arbor, MI 48109, USA
    • ,
  • Wen Ye

      Affiliations

    • Department of Biostatistics, The University of Michigan, Ann Arbor, MI 48109, USA

Received 26 July 2006 ,Revised 12 March 2007 ,Accepted 13 March 2007.

References 

  1. Deuschle M, Schweiger U, Weber B, Gotthardt U, Korner A, Schmider J, et al. Diurnal activity and pulsatility of the hypothalamus–pituitary–adrenal system in male depressed patients and healthy controls. J. Clin. Endocrinol. Metab. 1997;82:234–238
  2. Halbreich U, Asnis GM, Schindledecker R, Zurnoff B, Nathan RS. Cortisol secretion in endogenous depression. I. Basal plasma levels. Arch. Gen. Psychiatry. 1985;42:909–914
  3. Iranmanesh A, Lizarralde G, Veldhuis JD. Coordinate activation of the corticotropic axis by insulin-induced hypoglycemia: simultaneous estimates of beta-endorphin, adrenocorticotropin and cortisol secretion and disappearance in normal men. Acta Endocrinol. (Copenh.). 1993;128(6):521–528
  4. Knobil E. The GnRH pulse generator. Am. J. Obstet. Gynecol. 1990;163:1721–1727
  5. Linkowski P, Mendelwicz J, LeClercq R, Brasseur M, Hubain P, Goldstein J, et al. The 24 hour profile of ACTH and cortisol in major depressive illness. J. Clin. Endocrinol. Metab. 1985;61:429–434
  6. Midgley AR, Jaffe RB. Regulation of human gonadotropins. X. Episodic fluctuation of LH during the menstrual cycle. J. Clin. Endocrinol. Metab. 1971;33:962–969
  7. Mortola JF, Liu JH, Gillin JC, Rasmussen DD, Yen SS. Pulsatile rhythms of adrenocorticotropin (ACTH) and cortisol in women with endogenous depression: evidence for increased ACTH pulse frequency. J. Clin. Endocrinol. Metab. 1987;65:962–968
  8. Pfohl B, Sherman B, Schlecte J, Stone R. Pituitary/adrenal axis rhythm disturbances in psychiatric patients. Arch. Gen. Psychiatry. 1985;42:897–903
  9. Rubin RT, Poland RE, Lesser IM, Winston RA, Blodgett N. Neuroendocrine aspects of primary endogenous depression. I. Cortisol secretory dynamics in patients and matched controls. Arch. Gen. Psychiatry. 1987;44:328–336
  10. Sachar EJ, Hellman L, Roffwarg H, Halpern F, Fukushima D, Gallagher T. Disrupted 24-hour patterns of cortisol secretion in psychotic depression. Arch. Gen. Psychiatry. 1973;28:19–24
  11. Veldhuis JD, Evans WS, Johnson ML, Wills MR, Rogol AD. Physiological properties of the luteinizing hormone pulse signal: impact of intensive and extended venous sampling paradigms on its characterization in healthy men and women. J. Clin. Endocrinol. Metab. 1986;62:881–891
  12. Veldhuis JD, Carlson ML, Johnson ML. The pituitary gland secretes in bursts: appraising the nature of glandular secretory impulses by simultaneous multiple-parameter deconvolution of plasma hormone concentrations. Proc. Natl. Acad. Sci. USA. 1987;84(21):7686–7690
  13. Veldhuis JD, Iranmanesh A, Lizarralde G, Johnson ML. Amplitude modulation of a burstlike mode of cortisol secretion subserves the circadian glucocorticoid rhythm. Am. J. Physiol. 1989;257(1 Pt 1):E6–E14
  14. Veldhuis JD, Iranmanesh A, Naftolowitz D, Tatham N, Cassidy F, Carroll BJ. Corticotropin secretory dynamics in humans under low glucocorticoid feedback. J. Clin. Endocrinol. Metab. 2001;86:5554–5563
  15. Young EA, Ribiero SC. Sex differences in the ACTH response to 24H metyrapone in depression. Brain Res. 2006;1126:148–155
  16. Young EA, Carlson NE, Brown MB. 24H ACTH and cortisol pulsatility in depressed women. Neuropsychpoharmacology. 2001;25:267–276

PII: S0306-4530(07)00061-3

doi: 10.1016/j.psyneuen.2007.03.003

Psychoneuroendocrinology
Volume 32, Issue 5 , Pages 503-507 , June 2007

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