Psychoneuroendocrinology
Volume 34, Issue 3 , Pages 382-388 , April 2009

BDNF Val66Met polymorphism is associated with HPA axis reactivity to psychological stress characterized by genotype and gender interactions

  • Idan Shalev

      Affiliations

    • Neurobiology, Hebrew University, Jerusalem, Israel
    • ,
  • Elad Lerer

      Affiliations

    • Human Genetics, Hebrew University, Jerusalem, Israel
    • ,
  • Salomon Israel

      Affiliations

    • Psychology Department, Hebrew University, Jerusalem, Israel
    • ,
  • Florina Uzefovsky

      Affiliations

    • Psychology Department, Hebrew University, Jerusalem, Israel
    • ,
  • Inga Gritsenko

      Affiliations

    • S. Herzog Memorial Hospital, Jerusalem, Israel
    • ,
  • David Mankuta

      Affiliations

    • Hadassah Medical Organization, Department of Labor and Delivery, Jerusalem, Israel
    • ,
  • Richard P. Ebstein

      Affiliations

    • Psychology Department, Hebrew University, Jerusalem, Israel
    • S. Herzog Memorial Hospital, Jerusalem, Israel
    • Corresponding Author InformationCorresponding author at: Psychology Department, Hebrew University, Mt. Scopus campus, 91905 Jerusalem, Israel. Tel.: +972 2 5316855; fax: +972 2 5316853.
    • ,
  • Marsha Kaitz

      Affiliations

    • Psychology Department, Hebrew University, Jerusalem, Israel

Received 19 May 2008 ,Revised 24 August 2008 ,Accepted 26 September 2008.

References 

  1. Bartels M, Van den Berg M, Sluyter F, Boomsma DI, de Geus EJ. Heritability of cortisol levels: review and simultaneous analysis of twin studies. Psychoneuroendocrinology. 2003;28(2):121–137
  2. Bergstrom A, Jayatissa MN, Mork A, Wiborg O. Stress sensitivity and resilience in the chronic mild stress rat model of depression; an in situ hybridization study. Brain Res. 2008;1196:41–52
  3. Bueller JA, Aftab M, Sen S, Gomez-Hassan D, Burmeister M, Zubieta JK. BDNF Val66Met allele is associated with reduced hippocampal volume in healthy subjects. Biol. Psychiatry. 2006;59(9):812–815
  4. Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H, et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science. 2003;301(5631):386–389
  5. Chong RY, Oswald L, Yang X, Uhart M, Lin PI, Wand GS. The micro-opioid receptor polymorphism A118G predicts cortisol responses to naloxone and stress. Neuropsychopharmacology. 2006;31(1):204–211
  6. Dechant G, Neumann H. Neurotrophins. Adv. Exp. Med. Biol. 2002;513:303–334
  7. DeRijk RH, Wust S, Meijer OC, Zennaro MC, Federenko IS, Hellhammer DH, et al. A common polymorphism in the mineralocorticoid receptor modulates stress responsiveness. J. Clin. Endocrinol. Metab. 2006;91(12):5083–5089
  8. Dickerson SS, Kemeny ME. Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research. Psychol. Bull. 2004;130(3):355–391
  9. Egan MF, Kojima M, Callicott JH, Goldberg TE, Kolachana BS, Bertolino A, et al. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell. 2003;112(2):257–269
  10. Federenko IS, Nagamine M, Hellhammer DH, Wadhwa PD, Wust S. The heritability of hypothalamus pituitary adrenal axis responses to psychosocial stress is context dependent. J. Clin. Endocrinol. Metab. 2004;89(12):6244–6250
  11. Gater R, Tansella M, Korten A, Tiemens BG, Mavreas VG, Olatawura MO. Sex differences in the prevalence and detection of depressive and anxiety disorders in general health care settings: report from the World Health Organization Collaborative Study on Psychological Problems in General Health Care. Arch. Gen. Psychiatry. 1998;55(5):405–413
  12. Gotlib IH, Joormann J, Minor KL, Hallmayer J. HPA axis reactivity: a mechanism underlying the associations among 5-HTTLPR, stress, and depression. Biol. Psychiatry. 2007;63:847–851
  13. Grigoriadis S, Robinson GE. Gender issues in depression. Ann. Clin. Psychiatry. 2007;19(4):247–255
  14. Groves JO. Is it time to reassess the BDNF hypothesis of depression?. Mol. Psychiatry. 2007;12(12):1079–1088
  15. Gulliksson M, Burell G, Lundin L, Toss H, Svardsudd K. Psychosocial factors during the first year after a coronary heart disease event in cases and referents. Secondary Prevention in Uppsala Primary Health Care Project (SUPRIM). BMC Cardiovasc. Disord. 2007;7:36
  16. Kirschbaum C, Hellhammer DH. Salivary cortisol in psychobiological research: an overview. Neuropsychobiology. 1989;22(3):150–169
  17. Kirschbaum C, Kudielka BM, Gaab J, Schommer NC, Hellhammer DH. Impact of gender, menstrual cycle phase, and oral contraceptives on the activity of the hypothalamus–pituitary–adrenal axis. Psychosom. Med. 1999;61(2):154–162
  18. Kirschbaum C, Pirke KM, Hellhammer DH. The ‘Trier Social Stress Test’—a tool for investigating psychobiological stress responses in a laboratory setting. Neuropsychobiology. 1993;28(1–2):76–81
  19. Kirschbaum C, Wust S, Hellhammer D. Consistent sex differences in cortisol responses to psychological stress. Psychosom. Med. 1992;54(6):648–657
  20. Kudielka BM, Kirschbaum C. Sex differences in HPA axis responses to stress: a review. Biol. Psychol. 2005;69(1):113–132
  21. Kumsta R, Entringer S, Koper JW, van Rossum EF, Hellhammer DH, Wust S. Sex specific associations between common glucocorticoid receptor gene variants and hypothalamus–pituitary–adrenal axis responses to psychosocial stress. Biol. Psychiatry. 2007;62(8):863–869
  22. Lang UE, Hellweg R, Kalus P, Bajbouj M, Lenzen KP, Sander T, et al. Association of a functional BDNF polymorphism and anxiety-related personality traits. Psychopharmacology (Berl). 2005;180(1):95–99
  23. Legato MJ, Gelzer A, Goland R, Ebner SA, Rajan S, Villagra V, et al. Gender-specific care of the patient with diabetes: review and recommendations. Gend. Med. 2006;3(2):131–158
  24. Liew M, Pryor R, Palais R, Meadows C, Erali M, Lyon E, et al. Genotyping of single-nucleotide polymorphisms by high-resolution melting of small amplicons. Clin. Chem. 2004;50(7):1156–1164
  25. Lipsky RH, Marini AM. Brain-derived neurotrophic factor in neuronal survival and behavior-related plasticity. Ann. N.Y. Acad. Sci. 2007;1122:130–143
  26. McEwen BS. Central effects of stress hormones in health and disease: understanding the protective and damaging effects of stress and stress mediators. Eur. J. Pharmacol. 2008;583:174–185
  27. Meltser I, Tahera Y, Simpson E, Hultcrantz M, Charitidi K, Gustafsson JK, et al. Estrogen receptor beta protects against acoustic trauma in mice. J. Clin. Invest. 2008;118(4):1563–1570
  28. Moller-Leimkuhler AM. Gender differences in cardiovascular disease and comorbid depression. Dialogues Clin. Neurosci. 2007;9(1):71–83
  29. Monteggia LM, Luikart B, Barrot M, Theobold D, Malkovska I, Nef S, et al. Brain-derived neurotrophic factor conditional knockouts show gender differences in depression-related behaviors. Biol. Psychiatry. 2007;61(2):187–197
  30. Noble RE. Depression in women. Metabolism. 2005;54(5 Suppl. 1):49–52
  31. O’Donnell K, Badrick E, Kumari M, Steptoe A. Psychological coping styles and cortisol over the day in healthy older adults. Psychoneuroendocrinology. 2008;33:601–611
  32. Olszewski TM, Varrasse JF. The neurobiology of PTSD: implications for nurses. J. Psychosoc. Nurs. Ment. Health Serv. 2005;43(6):40–47
  33. Pruessner JC, Kirschbaum C, Meinlschmid G, Hellhammer DH. Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change. Psychoneuroendocrinology. 2003;28(7):916–931
  34. Ridder S, Chourbaji S, Hellweg R, Urani A, Zacher C, Schmid W, et al. Mice with genetically altered glucocorticoid receptor expression show altered sensitivity for stress-induced depressive reactions. J. Neurosci. 2005;25(26):6243–6250
  35. Sasahara K, Shikimi H, Haraguchi S, Sakamoto H, Honda S, Harada N, et al. Mode of action and functional significance of estrogen-inducing dendritic growth, spinogenesis, and synaptogenesis in the developing Purkinje cell. J. Neurosci. 2007;27(28):7408–7417
  36. Seidah NG, Benjannet S, Pareek S, Chretien M, Murphy RA. Cellular processing of the neurotrophin precursors of NT3 and BDNF by the mammalian proprotein convertases. FEBS Lett. 1996;379(3):247–250
  37. Sohrabji F, Lewis DK. Estrogen–BDNF interactions: implications for neurodegenerative diseases. Front. Neuroendocrinol. 2006;27(4):404–414
  38. Southwick SM, Vythilingam M, Charney DS. The psychobiology of depression and resilience to stress: implications for prevention and treatment. Annu. Rev. Clin. Psychol. 2005;1:255–291
  39. Turner-Cobb JM. Psychological and stress hormone correlates in early life: a key to HPA-axis dysregulation and normalisation. Stress. 2005;8(1):47–57
  40. Uhart M, McCaul ME, Oswald LM, Choi L, Wand GS. GABRA6 gene polymorphism and an attenuated stress response. Mol. Psychiatry. 2004;9:998–1006
  41. Weidner G, Cain VS. The gender gap in heart disease: lessons from Eastern Europe. Am. J. Public Health. 2003;93(5):768–770
  42. Weiss LA, Pan L, Abney M, Ober C. The sex-specific genetic architecture of quantitative traits in humans. Nat. Genet. 2006;38(2):218–222
  43. Wust S, Van Rossum EF, Federenko IS, Koper JW, Kumsta R, Hellhammer DH. Common polymorphisms in the glucocorticoid receptor gene are associated with adrenocortical responses to psychosocial stress. J. Clin. Endocrinol. Metab. 2004;89(2):565–573

PII: S0306-4530(08)00259-X

doi: 10.1016/j.psyneuen.2008.09.017

Psychoneuroendocrinology
Volume 34, Issue 3 , Pages 382-388 , April 2009

Article Tools

* Image Usage & Resolution