Psychoneuroendocrinology
Volume 34, Issue 4 , Pages 532-539 , May 2009

Gender differences in rat erythrocyte and brain docosahexaenoic acid composition: Role of ovarian hormones and dietary omega-3 fatty acid composition

  • Robert K. McNamara

      Affiliations

    • Department of Psychiatry, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267-0516, United States
    • Corresponding Author InformationCorresponding author. Tel.: +1 513 558 5601; fax: +1 513 558 2955.
    • ,
  • Jessica Able

      Affiliations

    • Department of Psychiatry, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267-0516, United States
    • ,
  • Ronald Jandacek

      Affiliations

    • Department of Pathology, University of Cincinnati, Cincinnati, OH 45237, United States
    • ,
  • Therese Rider

      Affiliations

    • Department of Pathology, University of Cincinnati, Cincinnati, OH 45237, United States
    • ,
  • Patrick Tso

      Affiliations

    • Department of Pathology, University of Cincinnati, Cincinnati, OH 45237, United States

Received 18 April 2008 ,Revised 14 October 2008 ,Accepted 15 October 2008.

References 

  1. Asarian L, Geary N. Cyclic estradiol treatment normalizes body weight and restores physiological patterns of spontaneous feeding and sexual receptivity in ovariectomized rats. Horm. Behav. 2002;42:461–471
  2. Bakewell L, Burdge GC, Calder PC. Polyunsaturated fatty acid concentrations in young men and women consuming their habitual diets. Br. J. Nutr. 2006;96:93–99
  3. Becker JB, Arnold AP, Berkley KJ, Blaustein JD, Eckel LA, Hampson E, et al. Strategies and methods for research on sex differences in brain and behavior. Endocrinology. 2005;146:1650–1673
  4. Bourre JM, Dumont OS, Piciotti MJ, Pascal GA, Durand GA. Dietary alpha-linolenic acid deficiency in adult rats for 7 months does not alter brain docosahexaenoic acid content, in contrast to liver, heart and testes. Biochim. Biophys. Acta. 1992;1124:119–122
  5. Burdge GC, Jones AE, Wootton SA. Eicosapentaenoic and docosapentaenoic acids are the principal products of alpha-linolenic acid metabolism in young men. Br. J. Nutr. 2002;88:355–363
  6. Burdge GC, Wootton SA. Conversion of alpha-linolenic acid to eicosapentaenoic, docosapentaenoic and docosahexaenoic acids in young women. Br. J. Nutr. 2002;88:411–420
  7. Butcher RL, Collins WE, Fugo NW. Plasma concentration of LH, FSH, prolactin, progesterone and estradiol-17beta throughout the 4-day estrous cycle of the rat. Endocrinology. 1974;94:1704–1708
  8. Carrié I, Clément M, de Javel D, Francès H, Bourre JM. Specific phospholipid fatty acid composition of brain regions in mice. Effects of n-3 polyunsaturated fatty acid deficiency and phospholipid supplementation. J. Lipid Res. 2000;41:465–472
  9. Childs CE, Romeu-Nadal M, Burdge GC, Calder PC. Gender differences in the n-3 fatty acid content of tissues. Proc. Nutr. Soc. 2008;67:19–27
  10. Crowe FL, Skeaff CM, Green TJ, Gray AR. Serum n-3 long-chain PUFA differ by sex and age in a population-based survey of New Zealand adolescents and adults. Br. J. Nutr. 2008;99:168–174
  11. Deecher D, Andree TH, Sloan D, Schechter LE. From menarche to menopause: exploring the underlying biology of depression in women experiencing hormonal changes. Psychoneuroendocrinology. 2008;33:3–17
  12. De Vriese SR, Christophe AB, Maes M. Lowered serum n-3 polyunsaturated fatty acid (PUFA) levels predict the occurrence of postpartum depression: further evidence that lowered n-PUFAs are related to major depression. Life Sci. 2003;73:3181–3187
  13. Giltay EJ, Duschek EJ, Katan MB, Zock PL, Neele SJ, Netelenbos JC. Raloxifene and hormone replacement therapy increase arachidonic acid and docosahexaenoic acid levels in postmenopausal women. J. Endocrinol. 2004;182:399–408
  14. Giltay EJ, Gooren LJ, Toorians AW, Katan MB, Zock PL. Docosahexaenoic acid concentrations are higher in women than in men because of estrogenic effects. Am. J. Clin. Nutr. 2004;80:1167–1174
  15. Hakkarainen R, Partonen T, Haukka J, Virtamo J, Albanes D, Lönnqvist J. Is low dietary intake of omega-3 fatty acids associated with depression?. Am. J. Psychiatry. 2004;161:567–569
  16. Harris WS. Omega-3 fatty acids and cardiovascular disease: a case for omega-3 index as a new risk factor. Pharmacol. Res. 2007;55:217–223
  17. Hibbeln JR. Seafood consumption, the DHA content of mothers’ milk and prevalence rates of postpartum depression: a cross-national, ecological analysis. J. Affect. Disord. 2002;69:15–29
  18. Hibbeln JR, Makino KK, Martin CE, Dickerson F, Boronow J, Fenton WS. Smoking, gender, and dietary influences on erythrocyte essential fatty acid composition among patients with schizophrenia or schizoaffective disorder. Biol. Psychiatry. 2003;53:431–441
  19. Kessler RC. Epidemiology of women and depression. J. Affect. Disord. 2003;74:5–13
  20. Leng GC, Horrobin DF, Fowkes FG, Smith FB, Lowe GD, Donnan PT, et al. Plasma essential fatty acids, cigarette smoking, and dietary antioxidants in peripheral arterial disease. A population-based case–control study. Arterioscler. Thromb. 1994;14:471–478
  21. Levant B, Radel JD, Carlson SE. Reduced brain DHA content after a single reproductive cycle in female rats fed a diet deficient in n-3 polyunsaturated fatty acids. Biol. Psychiatry. 2006;60:987–990
  22. Levant B, Ozias MK, Carlson SE. Diet (n-3) polyunsaturated fatty acid content and parity interact to alter maternal rat brain phospholipid fatty acid composition. J. Nutr. 2006;136:2236–2242
  23. Levant B, Ozias MK, Carlson SE. Diet (n-3) polyunsaturated fatty acid content and parity affect liver and erythrocyte phospholipid fatty acid composition in female rats. J. Nutr. 2007;137:2425–2430
  24. Levant B, Ozias MK, Carlson SE. Specific brain regions of female rats are differentially depleted of docosahexaenoic acid by reproductive activity and an (n-3) fatty acid-deficient diet. J. Nutr. 2007;137:130–134
  25. Lewis SJ. Risk of cardiovascular disease as a woman ages. J. Reprod. Med. 2007;52:147–151
  26. McNamara RK, Hahn CG, Jandacek R, Rider T, Tso P, Stanford KE, et al. Selective deficits in the omega-3 fatty acid docosahexaenoic acid in the postmortem orbitofrontal cortex of patients with major depressive disorder. Biol. Psychiatry. 2007;62:17–24
  27. McNamara RK, Sullivan J, Richtand NM. Omega-3 fatty acid deficiency augments amphetamine-induced behavioral sensitization in adult mice: prevention by chronic lithium treatment. J. Psychiatr. Res. 2008;42:458–468
  28. Metcalfe LD, Schmitz AA, Pelka JR. Rapid preparation of fatty acid esters from lipids for gas chromatographic analysis. Anal. Chem. 1966;38:514–515
  29. Nikkari T, Luukkainen P, Pietinen P, Puska P. Fatty acid composition of serum lipid fractions in relation to gender and quality of dietary fat. Ann. Med. 1995;27:491–498
  30. Otto SJ, de Groot RH, Hornstra G. Increased risk of postpartum depressive symptoms is associated with slower normalization after pregnancy of the functional docosahexaenoic acid status. Prostaglandins Leukot. Essent. Fatty Acids. 2003;69:237–243
  31. Otto SJ, van Houwelingen AC, Badart-Smook A, Hornstra G. Changes in the maternal essential fatty acid profile during early pregnancy and the relation of the profile to diet. Am. J. Clin. Nutr. 2001;73:302–307
  32. Parker G, Gibson NA, Brotchie H, Heruc G, Rees AM, Hadzi-Pavlovic D. Omega-3 fatty acids and mood disorders. Am. J. Psychiatry. 2006;163:969–978
  33. Pawlosky R, Hibbeln J, Lin Y, Salem N. n-3 fatty acid metabolism in women. Br. J. Nutr. 2003;90:993–994
  34. Pawlosky RJ, Bacher J, Salem N. Ethanol consumption alters electroretinograms and depletes neural tissues of docosahexaenoic acid in rhesus monkeys: nutritional consequences of a low n-3 fatty acid diet. Alcohol Clin. Exp. Res. 2001;25:1758–1765
  35. Saunders KE, Hawton K. Suicidal behaviour and the menstrual cycle. Psychol. Med. 2006;36:901–912
  36. Sumino H, Ichikawa S, Murakami M, Nakamura T, Kanda T, Sakamaki T, et al. Effects of hormone replacement therapy on circulating docosahexaenoic acid and eicosapentaenoic acid levels in postmenopausal women. Endocr. J. 2003;50:51–59
  37. Tanskanen A, Hibbeln JR, Hintikka J, Haatainen K, Honkalampi K, Viinamäki H. Fish consumption, depression, and suicidality in a general population. Arch. Gen. Psychiatry. 2001;58:512–513
  38. Timonen M, Horrobin D, Jokelainen J, Laitinen J, Herva A, Räsänen P. Fish consumption and depression: the Northern Finland 1966 birth cohort study. J. Affect. Disord. 2004;82:447–452
  39. Xiao Y, Huang Y, Chen ZY. Distribution, depletion and recovery of docosahexaenoic acid are region-specific in rat brain. Br. J. Nutr. 2005;94:544–550

PII: S0306-4530(08)00287-4

doi: 10.1016/j.psyneuen.2008.10.013

Psychoneuroendocrinology
Volume 34, Issue 4 , Pages 532-539 , May 2009

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