Psychoneuroendocrinology
Volume 34, Issue 4 , Pages 555-560 , May 2009

Epigenetic regulation and gene expression of vasopressin and atrial natriuretic peptide in alcohol withdrawal

  • Thomas Hillemacher

      Affiliations

    • Department of Psychiatry and Psychotherapy, University Hospital Erlangen, Germany
    • Department of Psychiatry, Socialpsychiatry and Psychotherapy, Hannover Medical School, Germany
    • Corresponding Author InformationCorresponding author at: Department of Psychiatry, Socialpsychiatry and Psychotherapy, Hannover Medical School, Carl-Neuberg-Str. 1, D-30625 Hannover, Germany. Tel.: +49 511 5326561; fax: +49 511 5322415.
    • ,
  • Helge Frieling

      Affiliations

    • Department of Psychiatry and Psychotherapy, University Hospital Erlangen, Germany
    • ,
  • Katja Luber

      Affiliations

    • Department of Psychiatry and Psychotherapy, University Hospital Erlangen, Germany
    • ,
  • Ayfer Yazici

      Affiliations

    • Department of Psychiatry and Psychotherapy, University Hospital Erlangen, Germany
    • ,
  • Marc A.N. Muschler

      Affiliations

    • Department of Psychiatry and Psychotherapy, University Hospital Erlangen, Germany
    • ,
  • Bernd Lenz

      Affiliations

    • Department of Psychiatry and Psychotherapy, University Hospital Erlangen, Germany
    • ,
  • Julia Wilhelm

      Affiliations

    • Department of Psychiatry and Psychotherapy, University Hospital Erlangen, Germany
    • ,
  • Johannes Kornhuber

      Affiliations

    • Department of Psychiatry and Psychotherapy, University Hospital Erlangen, Germany
    • ,
  • Stefan Bleich

      Affiliations

    • Department of Psychiatry and Psychotherapy, University Hospital Erlangen, Germany
    • Department of Psychiatry, Socialpsychiatry and Psychotherapy, Hannover Medical School, Germany

Received 2 June 2008 ,Revised 14 September 2008 ,Accepted 22 October 2008.

References 

  1. Anton RF, Moak DH, Latham P. The obsessive compulsive drinking scale: a self-rated instrument for the quantification of thoughts about alcohol and drinking behavior. Alcohol. Clin. Exp. Res. 1995;19:92–99
  2. Anton RF, Moak DH, Latham PK. The obsessive compulsive drinking scale: a new method of assessing outcome in alcoholism treatment studies. Arch. Gen. Psychiatry. 1996;53:225–231
  3. Antoni FA, Hunter EF, Lowry PJ, Noble JM, Seckl JR. Atriopeptin: an endogenous corticotropin-release inhibiting hormone. Endocrinology. 1992;130:1753–1755
  4. Bleich S, Carl M, Bayerlein K, Reulbach U, Biermann T, Hillemacher T, et al. Evidence of increased homocysteine levels in alcoholism: the Franconian alcoholism research studies (FARS). Alcohol. Clin. Exp. Res. 2005;29:334–336
  5. Bleich S, Lenz B, Ziegenbein M, Beutler S, Frieling H, Kornhuber J, et al. Epigenetic DNA hypermethylation of the HERP gene promoter induces down-regulation of its mRNA expression in patients with alcohol dependence. Alcohol. Clin. Exp. Res. 2006;30:587–591
  6. Bönsch D, Lenz B, Kornhuber J, Bleich S. DNA hypermethylation of the alpha synuclein promoter in patients with alcoholism. Neuroreport. 2005;16:167–170
  7. Bönsch D, Reulbach U, Bayerlein K, Hillemacher T, Kornhuber J, Bleich S. Elevated alpha synuclein mRNA levels are associated with craving in patients with alcoholism. Biol. Psychiatry. 2004;56:984–986
  8. Döring WK, Herzenstiel MN, Krampe H, Jahn H, Pralle L, Sieg S, et al. Persistent alterations of vasopressin and N-terminal proatrial natriuretic peptide plasma levels in long-term abstinent alcoholics. Alcohol. Clin. Exp. Res. 2003;27:849–861
  9. Frieling H, Bleich S, Otten J, Römer KD, Kornhuber J, de Zwaan M, et al. Epigenetic down-regulation of atrial natriuretic peptide but not vasopressin mRNA expression in females with eating disorders is related to impulsivity. Neuropsychopharmacology. 2008;33:2605–2609
  10. Hillemacher T, Bayerlein K, Wilhelm J, Poleo D, Frieling H, Ziegenbein M, et al. Volume intake and craving in alcohol withdrawal. Alcohol Alcohol. 2006;41:61–65
  11. Hillemacher T, Bleich S, Frieling H, Schanze A, Wilhelm J, Sperling W, et al. Evidence of an association of leptin serum levels and craving in alcohol dependence. Psychoneuroendocrinology. 2007;32:87–90
  12. Hillemacher T, Frieling H, Hartl T, Wilhelm J, Kornhuber J, Bleich S. Promoter specific methylation of the dopamine transporter gene is altered in alcohol dependence and associated with craving. J. Psychiatr. Res. 2009;43:388–392
  13. Hillemacher T, Kraus T, Rauh J, Weiss J, Schanze A, Frieling H, et al. Role of appetite-regulating peptides in alcohol craving: an analysis in respect to subtypes and different consumption patterns in alcoholism. Alcohol. Clin. Exp. Res. 2007;31:950–954
  14. Kaye WH, Weltzin TE. Neurochemistry of bulimia nervosa. J. Clin. Psychiatry. 1991;52(Suppl.):21–28
  15. Keck ME. Corticotropin-releasing factor, vasopressin and receptor systems in depression and anxiety. Amino Acids. 2006;31:241–250
  16. Kessler MS, Murgatroyd C, Bunck M, Czibere L, Frank E, Jacob W, et al. Diabetes insipidus and, partially, low anxiety-related behaviour are linked to a SNP-associated vasopressin deficit in LAB mice. Eur. J. Neurosci. 2007;26:2857–2864
  17. Kiefer F, Andersohn F, Jahn H, Wolf K, Raedler TJ, Wiedemann K. Involvement of plasma atrial natriuretic peptide in protracted alcohol withdrawal. Acta Psychiatr. Scand. 2002;105:65–70
  18. Kiefer F, Jahn H, Jaschinski M, Holzbach R, Wolf K, Naber D, et al. Leptin: a modulator of alcohol craving?. Biol. Psychiatry. 2001;49:782–787
  19. Kiefer F, Jahn H, Kellner M, Naber D, Wiedemann K. Leptin as a possible modulator of craving for alcohol. Arch. Gen. Psychiatry. 2001;58:509–510
  20. Kristensen CB, Rasmussen S, Dahl A, Lauritsen B, Lund K. The withdrawal syndrome scale for alcohol and related psychoactive drugs: total scores for guidelines for treatment with Phenobarbital. Nord. Psykiatr. Tidsskr. 1986;40:139–146
  21. Laczi F, Valkusz Z, Laszlo FA, Wagner A, Jardanhazy T, Szasz A, et al. Effects of lysine–vasopressin and 1-deamino-8-d-arginine-vasopressin on memory in healthy individuals and diabetes insipidus patients. Psychoneuroendocrinology. 1982;7:185–193
  22. Landgraf R. Neuropeptides in anxiety modulation. Handb. Exp. Pharmacol. 2005;335–369
  23. Ohashi M, Fujio N, Nawata H, Kato K, Matsubayashi S, Tamai H, et al. Human atrial natriuretic polypeptide in plasma of patients with anorexia nervosa. Horm. Metab. Res. 1988;20:705–708
  24. Rodenhiser D, Mann M. Epigenetics and human disease: translating basic biology into clinical applications. CMAJ. 2006;174:341–348
  25. Strohle A, Feller C, Strasburger CJ, Heinz A, Dimeo F. Anxiety modulation by the heart? Aerobic exercise and atrial natriuretic peptide. Psychoneuroendocrinology. 2006;31:1127–1130
  26. Strohle A, Holsboer F. Stress responsive neurohormones in depression and anxiety. Pharmacopsychiatry. 2003;36(Suppl. 3):S207–S214
  27. Strohle A, Kellner M, Holsboer F, Wiedemann K. Anxiolytic activity of atrial natriuretic peptide in patients with panic disorder. Am. J. Psychiatry. 2001;158:1514–1516
  28. Surget A, Belzung C. Involvement of vasopressin in affective disorders. Eur. J. Pharmacol. 2008;583:340–349
  29. Wiedemann K, Jahn H, Yassouridis A, Kellner M. Anxiolyticlike effects of atrial natriuretic peptide on cholecystokinin tetrapeptide-induced panic attacks: preliminary findings. Arch. Gen. Psychiatry. 2001;58:371–377

PII: S0306-4530(08)00292-8

doi: 10.1016/j.psyneuen.2008.10.019

Psychoneuroendocrinology
Volume 34, Issue 4 , Pages 555-560 , May 2009

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