Psychoneuroendocrinology
Volume 34, Issue 9 , Pages 1272-1283 , October 2009

Hypothalamic–pituitary–adrenal axis dysregulation in depressed children and adolescents: A meta-analysis

Received 6 January 2009 ,Revised 9 March 2009 ,Accepted 24 March 2009.

References 

  1. Beaton EA, Schmidt LA, Ashbaugh AR, Santesso DL, Martin M. Low salivary cortisol levels among socially anxious young adults: preliminary evidence from a selected and a non-selected sample. Pers. Individ. Dif. 2006;41:1217–1228
  2. Birmaher B, Dahl R, Perel J, Williamson D, Nelson B, Stull S, et al. Corticotropin-releasing hormone challenge in prepubertal major depression. Biol. Psychiatry. 1996;39:267–277
  3. Birmaher B, Dahl R, Ryan N, Rabinovich H, Ambrosini P, Al-Shabbout M, et al. The dexamethasone suppression test in adolescent outpatients with major depressive disorder. Am. J. Psychiatry. 1992;149:1040–1045
  4. Birmaher B, Heydl P. Biological studies in depressed children and adolescents. Int. J. Neuropsychopharmacol. 2001;4:149–157
  5. Birmaher B, Ryan N, Williamson D, Brent D, Kaufman J, Dahl R, et al. Childhood and adolescent depression: a review of the past 10 years. Part I. J. Am. Acad. Child Adolesc. Psychiatry. 1996;35:1427–1439
  6. Burke H, Davis M, Otte C, Mohr D. Depression and cortisol responses to psychological stress: a meta-analysis. Psychoneuroendocrinology. 2005;30:846–856
  7. Casat C, Arana G, Powell K. The DST in children and adolescents with major depressive disorder. Am. J. Psychiatry. 1989;146:503–507
  8. Casat C, Pearson D, Ruiz-Nazario J, Rhoades H. Serial dexamethasone suppression tests (DST) in recently hospitalized children. Biol. Psychiatry. 1994;36:203–205
  9. Christensen M, Kessing L. The hypothalamo–pituitary–adrenal axis in major affective disorder: a review. Nord. J. Psychiat. 2001;55:359–363
  10. Coplan JD, Moreau D, Chaput F, Martinez J, Hoven C, Mandell D, et al. Salivary cortisol concentrations before and after carbon-dioxide inhalations in children. Biol. Psychiatry. 2002;51:326–333
  11. Dahl RE, Kaufman J, Ryan N, Perel J, Al-Shabbout M, Birmaher B, et al. The dexamethasone suppression test in children and adolescents: a review and a controlled study. Biol. Psychiatry. 1992;32:109–126
  12. Dahl R, Puig-Antich J, Ryan N, Nelson B, Novacenko H, Twomey J, et al. Cortisol secretion in adolescents with major depressive disorder. Acta Psychiat. Scand. 1989;80:18–26
  13. Dahl R, Ryan N, Puig-Antich J, Nguyen N, Al Shabbout M, Meyer V, et al. 24-Hour cortisol measures in adolescents with major depression: a controlled study. Biol. Psychiatry. 1991;30:25–36
  14. Dickerson S, Kemeny M. Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research. Psychol. Bull. 2004;130:355–391
  15. Doherty MB, Madansky D, Kraft J, Carter-Ake LL, Rosenthal PA, Coughlin BF. Cortisol dynamics and test performance of the dexamethasone suppression test in 97 psychiatrically hospitalized children aged 3–16 years. J. Am. Acad. Child Psychiatry. 1986;25:400–408
  16. Dorn LD, Burgess ES, Susman EJ, Von Eye A, DeBellis MD, Gold PW, et al. Response to oCRH in depressed and nondepressed adolescents: does gender make a difference?. J. Am. Acad. Child Adolesc. Psychiatry. 1996;35:764–773
  17. Duval S, Tweedie R. Trim and Fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics. 2000;56:455–463
  18. Edwards S, Clow A, Evans P, Hucklebridge F. Exploration of the awakening cortisol response in relation to diurnal cortisol secretory activity. Life Sci. 2001;68:2093–2103
  19. Extein I, Rosenberg G, Pottash A, Gold M. The dexamethasone suppression test in depressed adolescents. Am. J. Psychiatry. 1982;139:1617–1619
  20. Feder A, Coplan J, Goetz R, Mathew S, Pine D, Dahl R, et al. Twenty-four-hour cortisol secretion patterns in prepubertal children with anxiety or depressive disorders. Biol. Psychiatry. 2004;56:198–204
  21. Forbes E, Williamson D, Ryan N, Birmaher B, Axelson D, Dahl R. Peri-sleep-onset cortisol levels in children and adolescents with affective disorders. Biol. Psychiatry. 2006;59:24–30
  22. Fristad M, Weller E, Weller R, Teare M, Preskorn S. Self-report vs biological markers in assessment of childhood depression. J. Affect. Disord. 1988;15:339–345
  23. Gillespie C, Nemeroff C. Hypercortisolemia and depression. Psychosom. Med. 2005;67(Suppl. 1):S26–S28
  24. Goodyer I, Herbert J, Altham PM. Adrenal steroid secretion and major depression in 8- to 16-year-olds. III. Influence of cortisol/DHEA ratio at presentation on subsequent rates of disappointing life events and persistent major depression. Psychol. Med. 1998;28:265–273
  25. Goodyer I, Herbert J, Altham P, Pearson J, Secher S, Shiers H. Adrenal secretion during major depression in 8- to 16-year-olds. I. Altered diurnal rhythms in salivary cortisol and dehydroepiandrosterone (DHEA) at presentation. Psychol. Med. 1996;26:245–256
  26. Goodyer I, Herbert J, Moor S, Altham P. Cortisol hypersecretion in depressed school-aged children and adolescents. Psychiatry Res. 1991;37:237–244
  27. Goodyer I, Herbert J, Tamplin A. Psychoendocrine antecedents of persistent first-episode major depression in adolescents: a community-based longitudinal enquiry. Psychol. Med. 2003;33:601–610
  28. Goodyer I, Herbert J, Tamplin A, Altham P. First-episode major depression in adolescents: affective, cognitive and endocrine characteristics of risk status and predictors of onset. Br. J. Psychiatry. 2000;176:142–149
  29. Goodyer I, Herbert J, Tamplin A, Altham P. Recent life events, cortisol, dehydroepiandrosterone and the onset of major depression in high-risk adolescents. Br. J. Psychiatry. 2000;177:499–504
  30. Goodyer I, Park R, Herbert J. Psychosocial and endocrine features of chronic first-episode major depression in 8-16 year olds. Biol. Psychiatry. 2001;50:351–357
  31. Grissom R, Kim J. Effect Sizes for Research: A Broad Practical Approach. Mahwah, NJ: Lawrence Erlbaum Associates; 2005;
  32. Ha H, Kaplan S, Foley C. The dexamethasone suppression test in adolescent psychiatric patients. Am. J. Psychiatry. 1984;141:421–423
  33. Hall J, Rosenthal R. Interpreting and evaluating meta-analysis. Eval. Health Prof. 1995;18:393–407
  34. Halligan SL, Herbert J, Goodyer I, Murray L. Disturbances in morning cortisol secretion in association with maternal postnatal depression predict subsequent depressive symptomatology in adolescents. Biol. Psychiatry. 2007;62:40–46
  35. Hedges L. Estimation of effect size from a series of independent experiments. Psychol. Bull. 1982;92:490–499
  36. Herbert J, Goodyer I, Altham P, Pearson J, Secher S, Shiers H. Adrenal secretion and major depression in 8- to 16-year olds. II. Influences of co-morbidity at presentation. Psychol. Med. 1996;26:257–264
  37. Holsboer F. Neuroendocrinology of mood disorders. In:  Bloom F,  Kupfer D editor. Psychopharmacology: The Fourth Generation of Progress. New York: Raven Press; 1995;p. 957–969
  38. van Houwelingen H, Arends L, Stijnen T. Advanced methods in meta-analysis: multivariate approach and meta-regression. Stat. Med. 2002;21:589–624
  39. Hsu L, Molcan K, Cashman M, Lee S, Lohr J, Hindmarsh D. The dexamethasone suppression test in adolescent depression. J. Am. Acad. Child Psychiatry. 1983;22:470–473
  40. Ioannidis J. Interpretation of tests of heterogeneity and bias in meta-analysis. J. Eval. Clin. Pract. 2008;14:951–957
  41. Kalaian H, Raudenbush S. A multivariate mixed linear model for meta-analysis. Psychol. Methods. 1996;1:227–235
  42. Kaufman J, Birmaher B, Perel J, Dahl R, Moreci P, Nelson B, et al. The corticotropin-releasing hormone challenge in depressed abused, depressed nonabused, and normal control children. Biol. Psychiatry. 1997;42:669–679
  43. Kaufman J, Martin A, King RA, Charney D. Are child-, adolescent-, and adult-onset depression one and the same disorder?. Biol. Psychiatry. 2001;49:980–1001
  44. de Kloet C, Vermetten E, Geuze E, Kavelaars A, Heijnen C, Westenberg H. Assessment of HPA axis function in posttraumatic stress disorder: pharmacological and non-pharmacological challenge tests, a review. J. Psychiatr. Res. 2006;40:550–567
  45. Livingston R, Reis C, Ringdahl I. Abnormal dexamethasone suppression test results in depressed and nondepressed children. Am. J. Psychiatry. 1984;141:106–108
  46. Luby JL, Heffelfinger A, Mrakotsky C, Brown K, Hessler M, Spitznagel E. Alterations in stress cortisol reactivity in depressed preschoolers relative to psychiatric and no-disorder comparison groups. Arch. Gen. Psychiatry. 2003;60:1248–1255
  47. Luby JL, Mrakotsky C, Heffelfinger A, Brown K, Spitznagel E. Characteristics of depressed preschoolers with and without anhedonia: evidence for a melancholic depressive subtype in young children. Am. J. Psychiatry. 2004;161:1998–2004
  48. Mann JJ, Currier D, Stanley B, Oquendo MA, Amsel LV, Ellis SP. Can biological tests assist prediction of suicide in mood disorders?. Int. J. Neuropsychopharmacol. 2006;9:465–474
  49. Mannie Z, Harmer C, Cowen P. Increased waking salivary cortisol levels in young people at familial risk of depression. Am. J. Psychiatry. 2007;164:617–621
  50. Naylor M, Greden J, Alessi N. Plasma dexamethasone levels in children given the dexamethasone suppression test. Biol. Psychiatry. 1990;27:592–600
  51. Nelson JC, Davis JM. DST studies in psychotic depression: a meta-analysis. Am. J. Psychiatry. 1997;154:1497–1503
  52. Normand S. Tutorial in biostatistics meta-analysis: formulating, evaluating, combining, and reporting. Stat. Med. 1999;18:321–359
  53. Petty L, Asarnow J, Carlson G, Lesser L. The dexamethasone suppression test in depressed, dysthymic, and nondepressed children. Am. J. Psychiatry. 1985;142:631–633
  54. Pfeffer CR, Stokes P, Weiner A, Shindledecker R, Faughnan L, Mintz M, et al. Psychopathology and plasma cortisol responses to dexamethasone in prepubertal psychiatric inpatients. Biol. Psychiatry. 1989;26:677–689
  55. Puig-Antich J, Dahl R, Ryan N, Novacenko H, Goetz D, Goetz R, et al. Cortisol secretion in prepubertal children with major depressive disorder. Episode and recovery. Arch. Gen. Psychiatry. 1989;46:801–809
  56. Rao U, Ryan ND, Dahl RE, Birmaher B, Rao R, Williamson DE, et al. Factors associated with the development of substance use disorder in depressed adolescents. J. Am. Acad. Child Adolesc. Psychiatry. 1999;38:1109–1117
  57. Rao U, Poland RE. Electroencephalographic sleep and hypothalamic–pituitary–adrenal changes from episode to recovery in depressed adolescents. J. Child Adolesc. Psychopharmacol. 2008;18:607–613
  58. Rao U, Dahl RE, Ryan ND, Birmaher B, Williamson DE, Giles DE, et al. The relationship between longitudinal clinical course and sleep and cortisol changes in adolescent depression. Biol. Psychiatry. 1996;40:474–484
  59. Rao U, Hammen C, Ortiz LR, Chen L, Poland RE. Effects of early and recent adverse experiences on adrenal response to psychosocial stress in depressed adolescents. Biol. Psychiatry. 2008;64:521–526
  60. Rao U, McCracken JT, Lutchmansingh P, Edwards C, Poland RE. Electroencephalographic sleep and urinary free cortisol in adolescent depression: a preliminary report of changes from episode to recovery. Biol. Psychiatry. 1997;41:369–373
  61. Ribeiro S, Tandon R, Grunhaus L, Greden J. The DST as a predictor of outcome in depression: a meta-analysis. Am. J. Psychiatry. 1993;150:1618–1629
  62. Robbins D, Alessi N, Yanchyshyn G, Colfer M. The dexamethasone suppression test in psychiatrically hospitalized adolescents. J. Am. Acad. Child Psychiatry. 1983;22:467–469
  63. Ronsaville D, Municchi G, Laney C, Cizza G, Meyer S, Haim A, et al. Maternal and environmental factors influence the hypothalamic–pituitary–adrenal axis response to corticotropin-releasing hormone infusion in offspring of mothers with or without mood disorders. Dev. Psychopathol. 2006;18:173–194
  64. Schmidt-Reinwald A, Pruessner J, Hellhammer D, Federenko I, Rohleder N, Schurmeyer T, et al. The cortisol response to awakening in relation to different challenge tests and a 12-hour cortisol rhythm. Life Sci. 1999;64:1653–1660
  65. Singer J. Using SAS PROC MIXED to fit multilevel models, hierarchical models, and individual growth models. J. Educ. Behav. Stat. 1998;24:323–355
  66. Steingard R, Biederman J, Keenan K, Moore C. Comorbidity in the interpretation of dexamethasone suppression test results in children: a review and report. Biol. Psychiatry. 1990;28:193–202
  67. Targum S, Capodanno A. The dexamethasone suppression test in adolescent psychiatric inpatients. Am. J. Psychiatry. 1983;140:589–591
  68. Videbech P, Ravnkilde B. Hippocampal volume and depression: a meta-analysis of MRI studies. Am. J. Psychiatry. 2004;161:1957–1966
  69. Young EA, Vazquez D, Jiang H, Pfeffer CR. Saliva cortisol and response to dexamethasone in children of depressed parents. Biol. Psychiatry. 2006;60:831–836

PII: S0306-4530(09)00099-7

doi: 10.1016/j.psyneuen.2009.03.016

Psychoneuroendocrinology
Volume 34, Issue 9 , Pages 1272-1283 , October 2009

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