Psychoneuroendocrinology
Volume 35, Issue 2 , Pages 289-296 , February 2010

The role of the serotonin transporter polymorphism for the endocrine stress response in newborns

  • Anett Mueller

      Affiliations

    • Department of Psychology, Technische Universitaet Dresden, Zellescher Weg 17, 01062 Dresden, Germany
    • ,
  • Burkhard Brocke

      Affiliations

    • Department of Psychology, Technische Universitaet Dresden, Zellescher Weg 17, 01062 Dresden, Germany
    • ,
  • Eva Fries

      Affiliations

    • Department of Psychology, Technische Universitaet Dresden, Zellescher Weg 17, 01062 Dresden, Germany
    • ,
  • Klaus-Peter Lesch

      Affiliations

    • Molecular and Clinical Psychobiology, Department of Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany
    • ,
  • Clemens Kirschbaum

      Affiliations

    • Department of Psychology, Technische Universitaet Dresden, Zellescher Weg 17, 01062 Dresden, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +49 351 4633 3356; fax: +49 351 4633 7274.

Received 20 November 2008 ,Revised 1 July 2009 ,Accepted 3 July 2009.

References 

  1. Alexander N, Kuepper Y, Schmitz A, Osinsky R, Kozyra E, Hennig J. Gene–environment interactions predict cortisol responses after acute stress: implications for the etiology of depression. Psychoneuroendocrinology. 2009;http://dx.doi.org/10.1016/j.psyneuen.2009.03.017
  2. Ansorge MS, Zhou M, Lira A, Hen R, Gingrich JA. Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice. Science. 2004;306:879–881
  3. Barr CS, Newman TK, Schwandt M, Shannon C, Dvoskin RL, Lindell SG, et al Sexual dichotomy of an interaction between early adversity and the serotonin transporter gene promoter variant in rhesus macaques. Proc. Natl. Acad. Sci. U.S.A. 2004;101:12358–12363
  4. Barr CS, Newman TK, Shannon C, Parker C, Dvoskin RL, Becker ML, et al Rearing condition and rh5-HTTLPR interact to influence limbic-hypothalamic-pituitary-adrenal axis response to stress in infant macaques. Biol. Psychiatry. 2004;55:733–738
  5. Bennett AJ, Lesch KP, Heils A, Long JC, Lorenz JG, Shoaf SE, et al. Early experience and serotonin transporter gene variation interact to influence primate CNS function. Mol. Psychiatry. 2002;7:118–122
  6. Buske-Kirschbaum A, Fischbach S, Rauh W, Hanker J, Hellhammer D. Increased responsiveness of the hypothalamus–pituitary–adrenal (HPA) axis to stress in newborns with atopic disposition. Psychoneuroendocrinology. 2004;29:705–711
  7. Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H, et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science. 2003;301:386–389
  8. Champoux M, Bennett A, Shannon C, Higley JD, Lesch KP, Suomi SJ. Serotonin transporter gene polymorphism, differential early rearing, and behavior in rhesus monkey neonates. Mol. Psychiatry. 2002;7:1058–1063
  9. Chrousos GP. The role of stress and the hypothalamic-pituitary-adrenal axis in the pathogenesis of the metabolic syndrome: neuro-endocrine and target tissue-related causes. Int. J. Obes. Relat. Metab. Disord. 2000;24(Suppl. 2):S50–S55
  10. Chrousos GP, Gold PW. The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis. JAMA. 1992;267:1244–1252
  11. Cohen S, Williamson G. Perceived stress in a probability sample of the United States. In:  Spacapan S,  Oskamp S editor. The Social Psychology of Health. Newbury Park, CA: Sage; 1988;
  12. Dallman MF, Akana SF, Cascio CS, Darlington DN, Jacobson L, Levin N. Regulation of Acth-secretion—variations on a theme of B. Rec. Prog. Horm. Res. 1987;43:113–173
  13. de Weerth C, Buitelaar JK. Childbirth complications affect young infants’ behavior. Eur. Child Adolesc. Psychiatry. 2007;16:379–388
  14. Eley TC, Sugden K, Corsico A, Gregory AM, Sham P, McGuffin P, et al. Gene–environment interaction analysis of serotonin system markers with adolescent depression. Mol. Psychiatry. 2004;9:908–915
  15. Fries E, Hesse J, Hellhammer J, Hellhammer DH. A new view on hypocortisolism. Psychoneuroendocrinology. 2005;30:1010–1016
  16. Fuller RW. Serotonin receptors involved in regulation of pituitary–adrenocortical function in rats. Behav. Brain Res. 1996;73:215–219
  17. Gathwala G, Narayanan I. Cesarean section and delayed contact: effect on baby's behaviour. Indian Pediatr. 1990;27:1295–1299
  18. Gelernter J, Kranzler H, Cubells JF. Serotonin transporter protein (SLC6A4) allele and haplotype frequencies and linkage disequilibria in African- and European-American and Japanese populations and in alcohol-dependent subjects. Hum. Gen. 1997;101:243–246
  19. Gillespie NA, Whitfield JB, Williams B, Heath AC, Martin NG. The relationship between stressful life events, the serotonin transporter (5-HTTLPR) genotype and major depression. Psychol. Med. 2005;35:101–111
  20. Gitau R, Cameron A, Fisk NM, Glover V. Fetal exposure to maternal cortisol. Lancet. 1998;352:707–708
  21. Gotlib IH, Joormann J, Minor KL, Hallmayer J. HPA axis reactivity: a mechanism underlying the associations among 5-HTTLPR, stress, and depression. Biol. Psychiatry. 2008;63:847–851
  22. Gunnar MR, Connors J, Isensee J, Wall L. Adrenocortical activity and behavioral distress in human newborns. Dev. Psychobiol. 1988;21:297–310
  23. Hariri AR, Drabant EM, Munoz KE, Kolachana LS, Mattay VS, Egan MF, et al. A susceptibility gene for affective disorders and the response of the human amygdala. Arch. Gen. Psychiatry. 2005;62:146–152
  24. Hariri AR, Drabant EM, Weinberger DR. Imaging genetics: perspectives from studies of genetically driven variation in serotonin function and corticolimbic affective processing. Biol. Psychiatry. 2006;
  25. Heils A, Teufel A, Petri S, Stober G, Riederer P, Bengel D, et al. Allelic variation of human serotonin transporter gene expression. J. Neurochem. 1996;66:2621–2624
  26. Hu X, Oroszi G, Chun J, Smith TL, Goldman D, Schuckit MA. An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism risk. Alcohol. Clin. Exp. Res. 2005;29:8–16
  27. Jans LA, Riedel WJ, Markus CR, Blokland A. Serotonergic vulnerability and depression: assumptions, experimental evidence and implications. Mol. Psychiatry. 2007;12:522–543
  28. Kendler KS, Kuhn JW, Vittum J, Prescott CA, Riley B. The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: a replication. Arch. Gen. Psychiatry. 2005;62:529–535
  29. Kirschbaum C, Hellhammer DH. Salivary cortisol in psychobiological research: an overview. Neuropsychobiology. 1989;22:150–169
  30. Kraemer GW, Moore CF, Newman TK, Barr CS, Schneider ML. Moderate level fetal alcohol exposure and serotonin transporter gene promoter polymorphism affect neonatal temperament and limbic-hypothalamic-pituitary-adrenal axis regulation in monkeys. Biol. Psychiatry. 2008;63:317–324
  31. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science. 1996;274:1527–1531
  32. Lowry CA. Functional subsets of serotonergic neurones: implications for control of the hypothalamic-pituitary-adrenal axis. J. Neuroendocrinol. 2002;14:911–923
  33. Lu A, Steiner MA, Whittle N, Vogl AM, Walser SM, Ableitner M, et al Conditional mouse mutants highlight mechanisms of corticotropin-releasing hormone effects on stress-coping behavior. Mol. Psychiatry. 2008;
  34. Maccari S, Darnaudery M, Morley-Fletcher S, Zuena AR, Cinque C, Van Reeth O. Prenatal stress and long-term consequences: implications of glucocorticoid hormones. Neurosci. Biobehav. Rev. 2003;27:119–127
  35. Mandelli L, Serretti A, Marino E, Pirovano A, Calati R, Colombo C. Interaction between serotonin transporter gene, catechol-O-methyltransferase gene and stressful life events in mood disorders. Int. J. Neuropsychopharmacol. 2007;10:437–447
  36. Mantagos S, Koulouris A, Vagenakis A. A simple stress test for the evaluation of hypothalamic-pituitary-adrenal axis during the first 6 months of life. J. Clin. Endocrinol. Metab. 1991;72:214–216
  37. Mathew SJ, Ho S. Etiology and neurobiology of social anxiety disorder. J. Clin. Psychiatry. 2006;67(Suppl. 12):9–13
  38. Matthews SG. Early programming of the hypothalamo-pituitary-adrenal axis. Trends Endocrinol. Metab. 2002;13:373–380
  39. McEwen BS. Glucocorticoids, depression, and mood disorders: structural remodeling in the brain. Metab. Clin. Exp. 2005;54(Suppl. 1):20–23
  40. Neumeister A, Konstantinidis A, Stastny J, Schwarz MJ, Vitouch O, Willeit M, et al Association between serotonin transporter gene promoter polymorphism (5HTTLPR) and behavioral responses to tryptophan depletion in healthy women with and without family history of depression. Arch. Gen. Psychiatry. 2002;59:613–620
  41. Ninan PT. Obsessive–compulsive disorder: implications of the efficacy of an SSRI, paroxetine. Psychopharmacol. Bull. 2003;37(Suppl. 1):89–96
  42. Ohara K, Nagai M, Tsukamoto T, Tani K, Suzuki Y. Functional polymorphism in the serotonin transporter promoter at the SLC6A4 locus and mood disorders. Biol. Psychiatry. 1998;44:550–554
  43. Schulz P, Schlotz W, Becker P. Trierer Inventar zum chronischen Stress. Göttingen Bern Toronto Seattle: Hogrefe Verlag; 2004;
  44. Seckl JR. Prenatal glucocorticoids and long-term programming. Eur. J. Endocrinol. 2004;151(Suppl. 3):U49–U62
  45. Selye H. A syndrome produced by diverse nocuous agents. Nature. 1936;138:32
  46. Sen S, Burmeister M, Ghosh D. Meta-analysis of the association between a serotonin transporter promoter polymorphism (5-HTTLPR) and anxiety-related personality traits. Am. J. Med. Genet. B: Neuropsychiatr. Genet. 2004;127:85–89
  47. Strobel A, Dreisbach G, Muller J, Goschke T, Brocke B, Lesch KP. Genetic variation of serotonin function and cognitive control. J. Cogn. Neurosci. 2007;
  48. Surtees PG, Wainwright NW, Willis-Owen SA, Luben R, Day NE, Flint J. Social adversity, the serotonin transporter (5-HTTLPR) polymorphism and major depressive disorder. Biol. Psychiatry. 2006;59:224–229
  49. Taylor A, Fisk NM, Glover V. Mode of delivery and subsequent stress response. Lancet. 2000;355:120
  50. Uher R, McGuffin P. The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: review and methodological analysis. Mol. Psychiatry. 2008;13:131–146
  51. Vieweg WV, Julius DA, Fernandez A, Beatty-Brooks M, Hettema JM, Pandurangi AK. Posttraumatic stress disorder: clinical features, pathophysiology, and treatment. Am. J. Med. 2006;119:383–390
  52. Wadhwa PD, Dunkel-Schetter C, Chicz-DeMet A, Porto M, Sandman CA. Prenatal psychosocial factors and the neuroendocrine axis in human pregnancy. Psychosom. Med. 1996;58:432–446
  53. Wadhwa PD, Glynn L, Hobel CJ, Garite TJ, Porto M, Chicz-DeMet A, et al. Behavioral perinatology: biobehavioral processes in human fetal development. Regul. Pept. 2002;108:149–157
  54. Weinstock M. Alterations induced by gestational stress in brain morphology and behaviour of the offspring. Prog. Neurobiol. 2001;65:427–451
  55. Welberg LA, Seckl JR. Prenatal stress, glucocorticoids and the programming of the brain. J. Neuroendocrinol. 2001;13:113–128
  56. Wendland JR, Martin BJ, Kruse MR, Lesch KP, Murphy DL. Simultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5-HTTLPR and rs25531. Mol. Psychiatry. 2006;11:224–226
  57. Wust S, Entringer S, Federenko IS, Schlotz W, Hellhammer DH. Birth weight is associated with salivary cortisol responses to psychosocial stress in adult life. Psychoneuroendocrinology. 2005;30:591–598

PII: S0306-4530(09)00213-3

doi: 10.1016/j.psyneuen.2009.07.002

Psychoneuroendocrinology
Volume 35, Issue 2 , Pages 289-296 , February 2010

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