« Previous
Next »
Psychoneuroendocrinology
Volume 35, Issue 2
, Pages 297-304
, February 2010
Ghrelin increases slow wave sleep and stage 2 sleep and decreases stage 1 sleep and REM sleep in elderly men but does not affect sleep in elderly women
References
- . Plasma ghrelin levels in healthy elderly volunteers: the levels of acylated ghrelin in elderly females correlate positively with serum IGF-I levels and bowel movement frequency and negatively with systolic blood pressure. J. Endocrinol. 2006;188:333–344
- . Neuroendocrine responses to a novel growth hormone secretagogue, L-692,429, in healthy older subjects. J. Clin. Endocrinol. Metab. 1994;79:943–949
- . Ghrelin secretion in humans is sexually dimorphic, suppressed by somatostatin, and not affected by the ambient growth hormone levels. J. Clin. Endocrinol. Metab. 2003;88:2180–2184
- . Women sleep objectively better than men and the sleep of young women is more resilient to external stressors: effects of age and menopause. J. Sleep Res. 2009;18:221–228
- . Cortisol enhances non-REM sleep and growth hormone secretion in elderly subjects. Neurobiol. Aging. 1997;18:423–429
- . The endocrine response to ghrelin as a function of gender in humans in young and elderly subjects. J. Clin. Endocrinol. Metab. 2003;88:1537–1542
- . Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretogogue (MK-677) in healthy elderly subjects. J. Clin. Endocrinol. Metab. 1996;81:4249–4257
- . Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves sleep quality in man. Neuroendocrinology. 1997;66:278–286
- . The GH-releasing effect of ghrelin, a natural GH secretagogue, is only blunted by the infusion of exogenous somatostatin in humans. Clin. Endocrinol. (Oxf). 2002;56:643–648
- . Acute cortisol administration promotes sleep intensity in man. Neuropsychopharmacology. 2004;29:598–604
- . Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and the human. Endocr. Rev. 1998;19:717–797
- . Gender differences in polysomnographic sleep in young healthy sleepers. Chronobiol. Int. 2005;22:905–915
- . Reduced efficacy of growth hormone-releasing hormone in modulating sleep endocrine activity in the elderly. Neurobiol. Aging. 1997;18:491–495
- . Effects of hormone therapy with estrogen and/or progesterone on sleep pattern in postmenopausal women. Int. J. Gynaecol. Obstet. 2008;103:207–212
- . Electroencephalographic sleep profiles and hypothalamic–pituitary–adrenocortical (HPA)-activity in kindergarten children: early indication of poor sleep quality associated with increased cortisol secretion. J. Psychiatr. Res. 2008;42:532–543
- . Effect of zopiclone and temazepam on sleep EEG parameters, psychomotor and memory functions in healthy elderly volunteers. Psychopharmacology (Berl). 2000;147:384–396
- . Effects of intravenous corticotropin-releasing hormone upon sleep-related growth hormone surge and sleep EEG in man. Neuroendocrinology. 1988;48:32–38
- . Sleep-promoting effects of growth hormone-releasing hormone in normal men. Am. J. Physiol. 1993;264:E594–E598
- . Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: a key role for bioavailable estrogen. J. Clin. Endocrinol. Metab. 1998;83:2266–2274
- . Ghrelin alone or co-administered with GHRH or CRH increases non-REM sleep and decreases REM sleep in young males. Psychoneuroendocrinology. 2008;33:497–506
- . Ghrelin suppresses secretion of luteinizing hormone in humans. J. Clin. Endocrinol. Metab. 2007;92:3202–3205
- . Ghrelin enhances the nocturnal secretion of cortisol and growth hormone in young females without influencing sleep. Psychoneuroendocrinology. 2007;32:1079–1085
- . Ghrelin administered in the early morning increases secretion of cortisol and growth hormone without affecting sleep. Psychoneuroendocrinology. 2007;32:287–292
- . Ghrelin suppresses secretion of follicle stimulating hormone (FSH) in males. Clin. Endocrinol. (Oxf). 2009;70:920–923
- . Nocturnal ghrelin pulsatility and response to growth hormone secretagogues in healthy men. Am. J. Physiol. Endocrinol. Metab. 2004;287:E506–E512
- . Effect of acute corticotropin releasing factor on pituitary-adrenocortical responsiveness in elderly women and men. J. Endocrinol. Invest. 1998;21:449–453
- . Homologous and heterologous regulation of pituitary receptors for ghrelin and growth hormone-releasing hormone. Endocrinology. 2004;145:3182–3189
- . Greater efficacy of episodic than continuous growth hormone-releasing hormone (GHRH) administration in promoting slow-wave sleep (SWS). J. Clin. Endocrinol. Metab. 1996;81:1009–1013
- . Systemic growth hormone-releasing hormone (GHRH) impairs sleep in healthy young women. Psychoneuroendocrinology. 2007;32:1021–1027
- . Effect of repeated gaboxadol administration on night sleep and next-day performance in healthy elderly subjects. Neuropsychopharmacology. 2005;30:833–841
- . The effect of growth hormone administration on human sleep: a dose-response study. Biol. Psychiatry. 1980;15:613–618
- . Nocturnal levels of ghrelin and leptin and sleep in chronic insomnia. Psychoneuroendocrinology. 2009;34:540–545
- . Ghrelin is released from rat hypothalamic explants and stimulates corticotrophin-releasing hormone and arginine-vasopressin. Horm. Metab. Res. 2003;35:455–459
- . Spontaneous 24
h ghrelin secretion pattern in fasting subjects: maintenance of a meal-related pattern. Eur. J. Endocrinol. 2005;152:845–850 - . Circadian and circannual variations of FSH, LH, testosterone, dehydroepiandrosterone-sulfate (DHEA-S) and 17-hydroxy progesterone (17 OH-Prog) in elderly men and women. Endocrinologie. 1985;23:223–246
- . Sleep in mice with nonfunctional growth hormone-releasing hormone receptors. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2003;284:R131–R139
- . A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects. Los Angeles: Brain Information Service Brain Research Institute, University of California; 1968;
- . Insomnia related to postmenopausal syndrome and hormone replacement therapy: sleep laboratory studies on baseline differences between patients and controls and double-blind, placebo-controlled investigations on the effects of a novel estrogen-progestogen combination (Climodien Lafamme) versus estrogen alone. J. Sleep Res. 2003;12:239–254
- . Effects of estrogen replacement therapy on rates of cyclic alternating patterns and hot-flush events during sleep in postmenopausal women: a pilot study. Clin. Ther. 1997;19:304–311
- . Effects of intravenous corticotropin-releasing hormone upon sleep EEG in young healthy women. J. Sleep Res. 2008;17:215–216
- . Progesterone reduces wakefulness in sleep EEG and has no effect on cognition in healthy postmenopausal women. Psychoneuroendocrinology. 2008;33:1124–1131
- . Relationship between ghrelin and the metabolic syndrome in the elderly: a longitudinal population-based study. Clin. Endocrinol. (Oxf). 2009;70:227–232
- . Effects of growth hormone-releasing hormone and somatostatin on sleep EEG and nocturnal hormone secretion in male controls. Neuroendocrinology. 1992;56:566–573
- . Ghrelin-induced sleep responses in ad libitum fed and food-restricted rats. Brain Res. 2006;1088:131–140
- . Ghrelin microinjection into forebrain sites induces wakefulness and feeding in rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2007;292:R575–R585
- . Spontaneous sleep and homeostatic sleep regulation in ghrelin knockout mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2007;293:R510–R517
- . Ghrelin strongly stimulates growth hormone release in humans. J. Clin. Endocrinol. Metab. 2000;85:4908–4911
- . Ultradian rhythmicity of ghrelin secretion in relation with GH, feeding behavior, and sleep–wake patterns in rats. Endocrinology. 2002;143:1353–1361
- . Sex difference in sleep-time preference and sleep need: a cross-sectional survey among Italian pre-adolescents, adolescents, and adults. Chronobiol. Int. 2008;25:745–759
- . Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr. Rev. 2004;25:426–457
- . Estradiol potentiates ghrelin-stimulated pulsatile growth hormone secretion in postmenopausal women. J. Clin. Endocrinol. Metab. 2006;91:3559–3565
- . Middle-aged men show higher sensitivity of sleep to the arousing effects of corticotropin-releasing hormone than young men: clinical implications. J. Clin. Endocrinol. Metab. 2001;86:1489–1495
- . Age-related sleep change: gender and estrogen effects on the subjective-objective sleep quality relationships of healthy, noncomplaining older men and women. J. Psychosom. Res. 2004;56:503–510
- . Ghrelin promotes slow-wave sleep in humans. Am. J. Physiol. Endocrinol. Metab. 2003;284:E407–E415
PII: S0306-4530(09)00218-2
doi: 10.1016/j.psyneuen.2009.07.007
© 2009 Elsevier Ltd. All rights reserved.
« Previous
Next »
Psychoneuroendocrinology
Volume 35, Issue 2
, Pages 297-304
, February 2010
