Psychoneuroendocrinology
Volume 35, Issue 3 , Pages 442-450 , April 2010

Low early morning plasma cortisol in posttraumatic stress disorder is associated with co-morbid depression but not with enhanced glucocorticoid feedback inhibition

  • M. Vythilingam

      Affiliations

    • Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892, USA
    • Corresponding Author InformationCorresponding author at: Psychological Health Strategic Operations, Force Health Protection & Readiness, Office of the Assistant Secretary of Defense (Health Affairs), Skyline 4, Suite 403, 5113 Leesburg Pike, Falls Church, VA 22041. Tel.: +1 301 594 1798; fax: +1 301 594 9959.
  • ,
  • J.M. Gill

      Affiliations

    • National Institutes of Nursing Research, Bethesda, MD 20892, USA
  • ,
  • D.A. Luckenbaugh

      Affiliations

    • Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892, USA
  • ,
  • P.W. Gold

      Affiliations

    • Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892, USA
  • ,
  • C. Collin

      Affiliations

    • Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892, USA
  • ,
  • O. Bonne

      Affiliations

    • Department of Psychiatry, Hadassah Hebrew University Medical Center, Jerusalem, Israel
  • ,
  • K. Plumb

      Affiliations

    • Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892, USA
  • ,
  • E. Polignano

      Affiliations

    • Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
  • ,
  • K. West

      Affiliations

    • Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892, USA
  • ,
  • D. Charney

      Affiliations

    • Mount Sinai School of Medicine, New York, NY, USA

Received 6 January 2009 ,Revised 29 June 2009 ,Accepted 13 August 2009.

References 

  1. Baker DG, Ekhator NN, et al. Higher levels of basal serial CSF cortisol in combat veterans with posttraumatic stress disorder. Am. J. Psychiatry. 2005;162(5):992–994
  2. Blake D, Weathers f, Ngy L, Kaloupek D, Charney D. A clinician rating scale for assessing lifetime and current PTSD: the CAPS. Behav. Therapist. 1990;13:187–188
  3. Blake DD, Weathers FW, et al. The development of a clinician-administered PTSD scale. J. Trauma. Stress. 1995;8(1):75–90
  4. Bremner D, Vermetten E, et al. Cortisol, dehydroepiandrosterone, and estradiol measured over 24hours in women with childhood sexual abuse-related posttraumatic stress disorder. J. Nerv. Ment. Dis. 2007;195(11):919–927
  5. Breslau N, Chilcoat HD, et al. Previous exposure to trauma and PTSD effects of subsequent trauma: results from the detroit area survey of trauma. Am. J. Psychiatry. 1999;156(6):902–907
  6. de Kloet C, Vermetten E, et al. Differences in the response to the combined DEX–CRH test between PTSD patients with and without co-morbid depressive disorder. Psychoneuroendocrinology. 2008;33(3):313–320
  7. de Kloet CS, Vermetten E, et al. Elevated plasma arginine vasopressin levels in veterans with posttraumatic stress disorder. J. Psychiatr. Res. 2008;42(3):192–198
  8. de Kloet CS, Vermetten E, et al. Enhanced cortisol suppression in response to dexamethasone administration in traumatized veterans with and without posttraumatic stress disorder. Psychoneuroendocrinology. 2007;32(3):215–226
  9. Fries E, Hesse J, et al. A new view on hypocortisolism. Psychoneuroendocrinology. 2005;30(10):1010–1016
  10. Geracioti TD, Baker DG, et al. Effects of trauma-related audiovisual stimulation on cerebrospinal fluid norepinephrine and corticotropin-releasing hormone concentrations in post-traumatic stress disorder. Psychoneuroendocrinology. 2008;33(4):416–424
  11. Geracioti TD, Loosen PT, et al. Low cerebrospinal fluid corticotropin-releasing hormone concentrations in eucortisolemic depression. Biol. Psychiatry. 1997;42(3):165–174
  12. Gold PW, Gabry KE, et al. Divergent endocrine abnormalities in melancholic and atypical depression: clinical and pathophysiologic implications. Endocrinol. Metab. Clin. North Am. 2002;31(1):37–62, vi
  13. Golier JA, Schmeidler J, et al. Twenty-four hour plasma cortisol and adrenocorticotropic hormone in Gulf War veterans: relationships to posttraumatic stress disorder and health symptoms. Biol. Psychiatry. 2007;62(10):1175–1178
  14. Griffin MG, Resick PA, et al. Enhanced cortisol suppression following dexamethasone administration in domestic violence survivors. Am. J. Psychiatry. 2005;162(6):1192–1199
  15. Heim C, Ehlert U, et al. The potential role of hypocortisolism in the pathophysiology of stress-related bodily disorders. Psychoneuroendocrinology. 2000;25(1):1–35
  16. Hellhammer J, Schlotz W, et al. Allostatic load, perceived stress, and health: a prospective study in two age groups. Ann. N. Y. Acad. Sci. 2004;1032:8–13
  17. Kanter ED, Wilkinson CW, et al. Glucocorticoid feedback sensitivity and adrenocortical responsiveness in posttraumatic stress disorder. Biol. Psychiatry. 2001;50(4):238–245
  18. Kessler RC, Sonnega A, et al. Posttraumatic stress disorder in the National Comorbidity Survey. Arch. Gen. Psychiatry. 1995;52(12):1048–1060
  19. McEwen BS. Protection and damage from acute and chronic stress: allostasis and allostatic overload and relevance to the pathophysiology of psychiatric disorders. Ann. N. Y. Acad. Sci. 2004;1032:1–7
  20. Meewisse ML, Reitsma JB, et al. Cortisol and post-traumatic stress disorder in adults: systematic review and meta-analysis. Br. J. Psychiatry. 2007;191:387–392
  21. Michael A, Jenaway A, et al. Altered salivary dehydroepiandrosterone levels in major depression in adults. Biol. Psychiatry. 2000;48(10):989–995
  22. Miller GE, Chen E, et al. If it goes up, must it come down? Chronic stress and the hypothalamic–pituitary–adrenocortical axis in humans. Psychol. Bull. 2007;133(1):25–45
  23. Momartin S, Silove D, et al. Comorbidity of PTSD and depression: associations with trauma exposure, symptom severity and functional impairment in Bosnian refugees resettled in Australia. J. Affect. Disord. 2004;80(2–3):231–238
  24. Olff M, Guzelcan Y, et al. HPA- and HPT-axis alterations in chronic posttraumatic stress disorder. Psychoneuroendocrinology. 2006;31(10):1220–1230
  25. Oquendo MA, Echavarria G, et al. Lower cortisol levels in depressed patients with comorbid post-traumatic stress disorder. Neuropsychopharmacology. 2003;28(3):591–598
  26. Rasmusson AM, Lipschitz DS, et al. Increased pituitary and adrenal reactivity in premenopausal women with posttraumatic stress disorder. Biol. Psychiatry. 2001;50(12):965–977
  27. Rasmusson AM, Vasek J, et al. An increased capacity for adrenal DHEA release is associated with decreased avoidance and negative mood symptoms in women with PTSD. Neuropsychopharmacology. 2004;29(8):1546–1557
  28. Rush AJ, Gullion CM, et al. The inventory of depressive symptomatology (IDS): psychometric properties. Psychol. Med. 1996;26(3):477–486
  29. Shalev AY, Sahar T, et al. A prospective study of heart rate response following trauma and the subsequent development of posttraumatic stress disorder. Arch. Gen. Psychiatry. 1998;55(6):553–559
  30. Shalev AY, Videlock EJ, et al. Stress hormones and post-traumatic stress disorder in civilian trauma victims: a longitudinal study. Part I. HPA axis responses. Int. J. Neuropsychopharmacol. 2008;11(3):365–372
  31. Sher L. The concept of post-traumatic mood disorder. Med. Hypotheses. 2005;65(2):205–210
  32. Simeon D, Knutelska M, et al. Hypothalamic–pituitary–adrenal axis function in dissociative disorders, post-traumatic stress disorder, and healthy volunteers. Biol. Psychiatry. 2007;61(8):966–973
  33. Sondergaard HP, Hansson LO, et al. Elevated blood levels of dehydroepiandrosterone sulphate vary with symptom load in posttraumatic stress disorder: findings from a longitudinal study of refugees in Sweden. Psychother. Psychosom. 2002;71(5):298–303
  34. Spivak B, Maayan R, et al. Elevated circulatory level of GABA(A)—antagonistic neurosteroids in patients with combat-related post-traumatic stress disorder. Psychol. Med. 2000;30(5):1227–1231
  35. Stewart JW, Quitkin FM, et al. Defining the boundaries of atypical depression: evidence from the HPA axis supports course of illness distinctions. J. Affect. Disord. 2005;86(2–3):161–167
  36. Touitou Y, Sulon J, et al. Adrenocortical hormones, ageing and mental condition: seasonal and circadian rhythms of plasma 18-hydroxy-11-deoxycorticosterone, total and free cortisol and urinary corticosteroids. J. Endocrinol. 1983;96(1):53–64
  37. Venkataraman S, Munoz R, et al. The hypothalamic–pituitary–adrenal axis in critical illness. Rev. Endocr. Metab. Disord. 2007;8(4):365–373
  38. Vythilingam M, Lawley M, et al. Hydrocortisone impairs hippocampal-dependent trace eyeblink conditioning in post-traumatic stress disorder. Neuropsychopharmacology. 2006;31(1):182–188
  39. Wheler GH, Brandon D, et al. Cortisol production rate in posttraumatic stress disorder. J. Clin. Endocrinol. Metab. 2006;91(9):3486–3489
  40. Yehuda R. Advances in understanding neuroendocrine alterations in PTSD and their therapeutic implications. Ann. N. Y. Acad. Sci. 2006;1071:137–166
  41. Yehuda R, Teicher MH, et al. Cortisol regulation in posttraumatic stress disorder and major depression: a chronobiological analysis. Biol. Psychiatry. 1996;40(2):79–88
  42. Young EA, Breslau N. Cortisol and catecholamines in posttraumatic stress disorder: an epidemiologic community study. Arch. Gen. Psychiatry. 2004;61(4):394–401

PII: S0306-4530(09)00250-9

doi: 10.1016/j.psyneuen.2009.08.006

Psychoneuroendocrinology
Volume 35, Issue 3 , Pages 442-450 , April 2010