Psychoneuroendocrinology
Volume 35, Issue 8 , Pages 1119-1132 , September 2010

Abnormal response to stress and impaired NPS-induced hyperlocomotion, anxiolytic effect and corticosterone increase in mice lacking NPSR1

  • Hongyan Zhu

      Affiliations

    • Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA
    • Graduate Program of Molecular and Developmental Biology, Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    • ,
  • Melissa K. Mingler

      Affiliations

    • Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA
    • ,
  • Melissa L. McBride

      Affiliations

    • Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA
    • ,
  • Andrew J. Murphy

      Affiliations

    • Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA
    • ,
  • David M. Valenzuela

      Affiliations

    • Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA
    • ,
  • George D. Yancopoulos

      Affiliations

    • Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA
    • ,
  • Michael T. Williams

      Affiliations

    • Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA
    • ,
  • Charles V. Vorhees

      Affiliations

    • Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 513 636 8622; fax: +1 513 636 3912.
    • ,
  • Marc E. Rothenberg

      Affiliations

    • Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 513 636 7210; fax: +1 513 636 3310.

Received 23 July 2009 ,Revised 15 January 2010 ,Accepted 19 January 2010.

References 

  1. Beck B, Fernette B, Stricker-Krongrad A. Peptide S is a novel potent inhibitor of voluntary and fast-induced food intake in rats. Biochem. Biophys. Res. Commun. 2005;332:859–865
  2. Bernier V, Stocco R, Bogusky MJ, Joyce JG, Parachoniak C, Grenier K, et al. Structure-function relationships in the neuropeptide S receptor: molecular consequences of the asthma-associated mutation N107I. J. Biol. Chem. 2006;281:24704–24712
  3. Boyer P. Do anxiety and depression have a common pathophysiological mechanism?. Acta Psychiatr. Scand. Suppl. 2000;406:24–29
  4. Brunskill EW, Ehrman LA, Williams MT, Klanke J, Hammer D, Schaefer TL, et al. Abnormal neurodevelopment, neurosignaling and behaviour in Npas3-deficient mice. Eur. J. Neurosci. 2005;22:1265–1276
  5. Camarda V, Rizzi A, Ruzza C, Zucchini S, Marzola G, Marzola E, et al. In vitro and in vivo pharmacological characterization of the neuropeptide s receptor antagonist [D-Cys(tBu)5]neuropeptide S. J. Pharmacol. Exp. Ther. 2009;328:549–555
  6. Chen E, Miller GE. Stress and inflammation in exacerbations of asthma. Brain Behav. Immun. 2007;21:993–999
  7. Cryan JF, Kelly PH, Neijt HC, Sansig G, Flor PJ, van Der Putten H. Antidepressant and anxiolytic-like effects in mice lacking the group III metabotropic glutamate receptor mGluR7. Eur. J. Neurosci. 2003;17:2409–2417
  8. Cryan JF, Mombereau C, Vassout A. The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice. Neurosci. Biobehav. Rev. 2005;29:571–625
  9. Crowe RR, Goedken R, Samuelson S, Wilson R, Nelson J, Noyes R. Genomewide survey of panic disorder. Am. J. Med. Genet. 2001;105:105–109
  10. D’Amato M, et al. Neuropeptide s receptor 1 gene polymorphism is associated with susceptibility to inflammatory bowel disease. Gastroenterology. 2007;133:808–817
  11. Garau, C., Okamura, N., Duangdao, D.M., Reinscheid, R.K., 2009. The role of neuropeptide S and its receptor in fear memory consolidation and extinction. 2009 Society for Neuroscience meeting abstract.
  12. Guerrini R, Camarda V, Trapella C, Calò G, Rizzi A, Ruzza C, et al. Synthesis and biological activity of human neuropeptide S analogues modified in position 5: identification of potent and pure neuropeptide S receptor antagonists. J. Med. Chem. 2009;52:524–529
  13. Han RW, Yin XQ, Chang M, Peng YL, Li W, Wang R. Neuropeptide S facilitates spatial memory and mitigates spatial memory impairment induced by N-methyl-D-aspartate receptor antagonist in mice. Neurosci. Lett. 2009;455:74–77
  14. Knowles JA, et al. Results of a genome-wide genetic screen for panic disorder. Am. J. Med. Genet. 1998;81:139–147
  15. Laitinen T, et al. Characterization of a common susceptibility locus for asthma-related traits. Science. 2004;304:300–304
  16. Leonard SK, Dwyer JM, Sukoff Rizzo SJ, Platt B, Logue SF, Neal SJ, et al. Pharmacology of neuropeptide S in mice: therapeutic relevance to anxiety disorders. Psychopharmacology (Berl). 2008;197:601–611
  17. Logue MW, Vieland VJ, Goedken RJ, Crowe RR. Bayesian analysis of a previously published genome screen for panic disorder reveals new and compelling evidence for linkage to chromosome 7. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2003;121B:95–99
  18. Lucki I, Dalvi A, Mayorga AJ. Sensitivity to the effects of pharmacologically selective antidepressants in different strains of mice. Psychopharmacology (Berl). 2001;155:315–322
  19. Maei HR, Zaslavsky K, Teixeira CM, Frankland PW. What is the most sensitive measure of water maze probe test performance?. Front. Integr. Neurosci. 2009;3:4–12
  20. Müller MB, Landgraf R, Preil J, Sillaber I, Kresse AE, Keck ME, et al. Selective activation of the hypothalamic vasopressinergic system in mice deficient for the corticotropin-releasing hormone receptor 1 is dependent on glucocorticoids. Endocrinology. 2000;141:4262–4269
  21. Niimi M. Centrally administered neuropeptide S activates orexin-containing neurons in the hypothalamus and stimulates feeding in rats. Endocrine. 2006;30:75–79
  22. Okamura N, Hashimoto K, Iyo M, Shimizu E, Dempfle A, Friedel S, et al. Gender-specific association of a functional coding polymorphism in the Neuropeptide S receptor gene with panic disorder but not with schizophrenia or attention-deficit/hyperactivity disorder. Prog. Neuropsychopharmacol. Biol. Psychiatry. 2007;31:1444–1448
  23. Okamura N, Habay SA, Zeng J, Chamberlin AR, Reinscheid RK. Synthesis and pharmacological in vitro and in vivo profile of 3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68), a selective antagonist of the neuropeptide S receptor. J. Pharmacol. Exp. Ther. 2008;325:893–901
  24. Pan D, Sciascia A, Vorhees CV, Williams MT. Progression of multiple behavioral deficits with various ages of onset in a murine model of Hurler syndrome. Brain Res. 2008;1188:241–253
  25. Paxinos G, Franklin KB. The Mouse Brain in Stereotaxic Coordinates. Compact 2nd edition. Elsevier Academic Press; 2004;
  26. Porsolt RD, Lepichon M, Jalfre M. Depression: a new animal model sensitive to antidepressant treatments. Nature. 1977;266:730–732
  27. Porsolt RD, Bertin A, Jalfre M. Behavioral despair in mice: a primary screening test for antidepressants. Arch. Int. Pharmacodyn. Ther. 1977;229:327–336
  28. Prickaerts J, Moechars D, Cryns K, Lenaerts I, van Craenendonck H, Goris I, et al. Transgenic mice overexpressing glycogen synthase kinase 3beta: a putative model of hyperactivity and mania. J. Neurosci. 2006;26:9022–9029
  29. Reinscheid RK, Xu YL, Okamura N, Zeng J, Chung S, Pai R, et al. Pharmacological characterization of human and murine neuropeptide s receptor variants. J. Pharmacol. Exp. Ther. 2005;315:1338–1345
  30. Rizzi A, Vergura R, Marzola G, Ruzza C, Guerrini R, Salvadori S, et al. Neuropeptide S is a stimulatory anxiolytic agent: a behavioural study in mice. Br. J. Pharmacol. 2008;154:471–479
  31. Santos J, Alonso C, Vicario M, Ramos L, Lobo B, Malagelada JR. Neuropharmacology of stress-induced mucosal inflammation: implications for inflammatory bowel disease and irritable bowel syndrome. Curr. Mol. Med. 2008;8:258–273
  32. Schramm NL, McDonald MP, Limbird LE. The alpha (2a)-adrenergic receptor plays a protective role in mouse behavioral models of depression and anxiety. J. Neurosci. 2001;21:4875–4882
  33. Shepherd JK, Grewal SS, Fletcher A, Bill DJ, Dourish CT. Behavioural and pharmacological characterisation of the elevated “zero-maze” as an animal model of anxiety. Psychopharmacology (Berl). 1994;116:56–64
  34. Smith KL, Patterson M, Dhillo WS, Patel SR, Semjonous NM, Gardiner JV, et al. Neuropeptide S stimulates the hypothalamo–pituitary–adrenal axis and inhibits food intake. Endocrinology. 2006;147:3510–3518
  35. Steele-Perkins G, Plachez C, Butz KG, Yang G, Bachurski CJ, Kinsman SL, et al. The transcription factor gene Nfib is essential for both lung maturation and brain development. Mol. Cell. Biol. 2005;25:685–698
  36. Valenzuela DM, et al. High-throughput engineering of the mouse genome coupled with high-resolution expression analysis. Nat. Biotechnol. 2003;21:652–659
  37. Van Meer P, Raber J. Mouse behavioural analysis in systems biology. Biochem. J. 2005;389:593–610
  38. Vendelin J, Pulkkinen V, Rehn M, Pirskanen A, Räisänen-Sokolowski A, Laitinen A, et al. Characterization of GPRA, a novel G protein-coupled receptor related to asthma. Am. J. Respir. Cell. Mol. Biol. 2005;33:262–270
  39. Vitale G, Filaferro M, Ruggieri V, Pennella S, Frigeri C, Rizzi A, et al. Anxiolytic-like effect of neuropeptide S in the rat defensive burying. Peptides. 2008;29:2286–2291
  40. Vorhees CV, Williams MT. Morris water maze: procedures for assessing spatial and related forms of learning and memory. Nat. Protoc. 2006;1:848–858
  41. Williams MT, Moran MS, Vorhees CV. Refining the critical period for methamphetamine-induced spatial deficits in the Morris water maze. Psychopharmacology (Berl). 2003;168:329–338
  42. Xu YL, Reinscheid RK, Huitron-Resendiz S, Clark SD, Wang Z, Lin SH, et al. Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects. Neuron. 2004;43:487–497
  43. Xu YL, Gall CM, Jackson VR, Civelli O, Reinscheid RK. Distribution of neuropeptide S receptor mRNA and neurochemical characteristics of neuropeptide S-expressing neurons in the rat brain. J. Comp. Neurol. 2007;500:84–102

PII: S0306-4530(10)00028-4

doi: 10.1016/j.psyneuen.2010.01.012

Psychoneuroendocrinology
Volume 35, Issue 8 , Pages 1119-1132 , September 2010

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