Psychoneuroendocrinology
Volume 35, Issue 8 , Pages 1148-1155 , September 2010

Giving birth to a new brain: Hormone exposures of pregnancy influence human memory

  • Laura M. Glynn

      Affiliations

    • Department of Psychology, Chapman University, One University Drive, Orange, CA 92866, United States
    • Department of Psychiatry and Human Behavior, University of California, Irvine, United States
    • Corresponding Author InformationCorrespondence address: Department of Psychology, Chapman University, United States. Tel.: +1 714 289 2075; fax: +1 714 997 6780.

Received 14 July 2009 ,Revised 18 November 2009 ,Accepted 26 January 2010.

References 

  1. Bardi M, French JA, Ramirez SM, Brent L. The role of the endocrine system in baboon maternal behavior. Biol. Psychiatry. 2004;55:724–732
  2. Bodensteiner KJ, Cain P, Ray AS, Hamula LA. Effects of pregnancy on spatial cognition in female Hooded Long-Evans rats. Horm. Behav. 2006;49:303–314
  3. Brett M, Baxendale S. Motherhood and memory: a review. Psychoneuroendocrinology. 2001;26:339–362
  4. Craig MC, Murphy DG. Oestrogen, cognition and the maturing female brain. J. Endocrinol. 2007;19:1–6
  5. de Kloet ER, Oitzl MS, Joëls M. Stress and cognition: are corticosteroids good or bad guys?. Trends Neurosci. 1999;22:422–426
  6. Diamond MC, Johnson RE, Ingram C. Brain plasticity induced by environment and pregnancy. Int. J. Neurosci. 1971;2:171–178
  7. DiPietro JA, Costigan KA, Gurewitsch ED. Maternal psychophysiological change during the second half of gestation. Biol. Psychol. 2005;69:23–38
  8. Fahrbach SE, Pfaff DW. Effect of preoptic region implants of dilute estradiol on the maternal behavior of ovariectomized nulliparous rats. Horm. Behav. 1986;20:354–363
  9. Fareri DS, Martin LN, Delgado MR. Reward-related processing in the human brain: developmental considerations. Dev. Psychopathol. 2008;20:1191–1211
  10. Fleming AS, Ruble D, Krieger H, Wong PY. Hormonal and experiential correlates of maternal responsiveness during pregnancy and the puerperium in human mothers. Horm. Behav. 1997;31:145–158
  11. Fleming AS, Steiner M, Corter C. Cortisol, hedonics and maternal responsiveness. Horm. Behav. 1997;32:85–98
  12. Forget H, Lacroix A, Somma M, Cohen H. Cognitive decline in patients with Cushing's syndrome. J. Int. Neuropsychol. Soc. 2000;6:20–29
  13. Gatewood JD, Morgan MD, Eaton M, McNamara IM, Stevens LF, Macbeth AH, et al. Motherhood mitigates aging-related decrements in learning and memory and positively affects brain aging in the rat. Brain Res. Bull. 2005;66:91–98
  14. Giedd JN, Lalonde FM, Celano MJ, White SL, Wallace GL, Lee NR, et al. Anatomical brain magnetic resonance imaging of typically developing children and adolescents. J Am. Acad. Child. Adolesc. Psychiatry. 2009;48:465–470
  15. Glynn, L.M., in press. Implications of maternal programming for fetal neurodevelopment. In: Zimmerman, A., Conners, S. (Eds.), Maternal Influences on Fetal Neurodevelopment. New Jersey, Springer Science+Business Media, LLC.
  16. Glynn LM, Dunkel Schetter C, Chicz-DeMet A, Hobel CJ, Sandman CA. Ethnic differences in adrenocorticotropic hormone, cortisol and corticotropin-releasing hormone during pregnancy. Peptides. 2007;28:1155–1161
  17. Glynn LM, Dunkel Schetter C, Hobel CJ, Sandman CA. Pattern of perceived stress and anxiety in pregnancy predicts preterm birth. Health Psychol. 2008;27:43–51
  18. Glynn LM, Schetter CD, Wadhwa PD, Sandman CA. Pregnancy affects appraisal of negative life events. J. Psychosom. Res. 2004;56:47–52
  19. Glynn LM, Wadhwa PD, Dunkel-Schetter C, Chicz-DeMet A, Sandman CA. When stress happens matters: effect of earthquake timing on stress responsivity in pregnancy. Am. J. Obstet. Gynecol. 2001;184
  20. Grillon C, Smith K, Haynos A, Nieman LK. Deficits in hippocampus-mediated Pavlovian conditioning in endogenous hypercortisolism. Biol. Psychiatry. 2004;56:837–843
  21. Haynes LE, Lendon CL, Barber DJ, Mitchell IJ. 17β-Oestradiol attenuates dexamethasone-induced lethal and sublethal neuronal damage in the striatum and hippocampus. Neuroscience. 2003;120:799–806
  22. Hennessy MB, Harney KS, Smotherman WP, Coyle S, Levine S. Adrenalectomy-induced deficits in maternal retrieval in the rat. Horm. Behav. 1977;9:222–227
  23. Henry JD, Rendell PG. A review of the impact of pregnancy on memory function. J. Clin. Exp. Neuropsychol. 2007;29:793–803
  24. Hinkelmann K, Moritz S, Botzenhardt J, Riedesel K, Wiedemann K, Kellner M, et al. Cognitive impairment in major depression: associated with salivary cortisol. Biol. Psychiatry. 2009;66:879–885
  25. Hrdy SB. Mother Nature: Maternal Instincts and How They Shape the Human Species. Ballantine Books; 2000;
  26. Keyser-Marcus L, Stafisso-Sandoz G, Geecke K, Jasnow A, Nightengale L, Lambert KG, et al. Alterations of medial preoptic area neurons following pregnancy and pregnancy-like steroidal treatment in the rat. Brain Res. Bull. 2001;55:737–745
  27. Kinsley CH, Lambert KG. The maternal brain. Sci. Am. 2006;294:72–79
  28. Kinsley CH, Lambert KG. Reproduction-induced neuroplasticity: natural behavioral and neuronal alterations associated with the production and care of offspring. J. Neuroendocrinol. 2008;20:515–525
  29. Kinsley CH, Madonia L, Gifford GW, Tureski K, Griffin GR, Lowry C, et al. Motherhood improves learning and memory. Nature. 1999;402:137–138
  30. Kinsley CH, Trainer R, Stafisso-Sandoz G, Quadros P, Marcus LK, Hearon C, et al. Motherhood and the hormones of pregnancy modify concentrations of hippocampal neuronal dendritic spines. Horm. Behav. 2006;131–142
  31. Kucera M, Francis W. Computational Analysis of Present Day American English. Providence, RI: Brown University Press; 1967;
  32. Love G, Torrey N, McNamara IM, Morgan M, Banks M, Hester NW, et al. Maternal experience produces long-lasting behavioral modifications in the rat. Behav. Neurosci. 2005;119:1084–1096
  33. Lupien SJ, McEwen BS. The acute effects of corticosteroids on cognition: integration of animal and human model studies. Brain Res. Rev. 1997;24:1–27
  34. Macbeth AH, Scharfman HE, MacLusky NJ, Gautrreaux C, Luine VN. Effects of multiparity on recognition memory, monoaminergic neurotransmitters, and brain-derived neurotrophic factor (BDNF). Horm. Behav. 2008;54:7–17
  35. MacLean PD. The Triune Brain in Evolution: Role in Paleocerebral Functions. New York: Plenum Press; 1990;
  36. Maestripieri D, Zehr JL. Maternal responsiveness increases during pregnancy and after estrogen treatment in macaques. Horm. Behav. 1998;34:223–230
  37. McEwen BS, Alves SE. Estrogen actions in the central nervous system. Endocr. Rev. 1999;20:279–307
  38. Mesiano S, Jaffe RB. Developmental and functional biology of the primate fetal adrenal cortex. Endocr. Rev. 1997;18:378–403
  39. Neumann ID. Brain mechanisms underlying emotional alterations in the peripartum period in rats. Depress. Anxiety. 2003;17:111–121
  40. Numan M. Hypothalamic neural circuits regulating maternal responsiveness toward infants. Behav. Cogn. Neurosci. Rev. 2006;5:163–190
  41. Petraglia F, Florio P, Nappi C, Genazzani AR. Peptide signaling in human placenta and membranes: autocrine, paracrine, and endocrine mechanisms. Endocr. Rev. 1996;17:156–186
  42. Protopopescu X, Butler T, Pan H, Root J, Altemus M, Polanecsky M, et al. Hippocampal structural changes across the menstrual cycle. Hippocampus. 2008;18:985–988
  43. Pryce CR, Abbott DH, Hodges JH, Martin RD. Maternal behavior is related to prepartum urinary estradiol levels in red-bellied tamarin monkeys. Physiol. Behav. 1988;44:717–726
  44. Rasia-Filho AA, Fabian C, Rigoti KM, Achaval M. Influence of sex, estrous cycle and motherhood on dendritic spine density in the rat medial amygdala revealed by the Golgi method. Neuroscience. 2004;126:839–847
  45. Raudenbush SW, Bryk AS. Hierarchical Linear Models: Application and Data Analysis Methods. vol. 1. Thousand Oaks: Sage Publications; 2002;
  46. Rees SL, Panesar S, Steinger M, Fleming AS. The effects of adrenalectomy and corticosterone replacement on maternal behavior in the postpartum rat. Horm. Behav. 2004;46:411–419
  47. Rose JC, Schwartz J, Green J, Kerr DR. Development of the corticotropin-releasing factor adrenocorticotropic hormone/beta-endorphin system in the mammalian fetus. In:  Polin RA,  Fox WW editor. Fetal and Neonatal Physiology. Philadelphia: W.B. Saunders; 1998;p. 2431–2442
  48. Rosenblatt JS, Mayer AD, Giordano AL. Hormonal basis during pregnancy for the onset of maternal behavior in the rat. Psychoneuroendocrinology. 1988;13:29–46
  49. Schulte HM, Weisner D, Allolio B. The corticotropin releasing hormone test in late pregnancy: lack of an adrenocorticotropin and cortisol response. Clin. Endocrinol. 1990;33:99–106
  50. Shingo T, Gregg C, Enwere E, Fujikawa H, Hassam R, Geary C, et al. Pregnancy-stimulated neurogenesis in the adult female forebrain mediated by prolactin. Science. 2003;299:117–120
  51. Smith R, Mesiano S, McGrath S. Hormone trajectories leading to human birth. Regul. Pept. 2002;108:159–164
  52. Smith R, Nicholson RC. Corticotropin releasing hormone and the timing of birth. Front. Biosci. 2007;12:912–918
  53. Spencer JL, Waters EM, Romeo RD, Wood GE, Milner TA, McEwen BS. Uncovering mechanisms of estrogen effects on hippocampal function. Front. Neuroendocrinol. 2008;29:219–237
  54. Stallings J, Fleming AS, Corter C, Worthman C, Steiner M. The effects of infant cries and odors on sympathy, cortisol, and autonomic responses in new mothers and nonpostpartum women. Parent. Sci. Pract. 2001;1:71–100
  55. Storment JM, Meyer M, Osol G. Estrogen augments the vasodilatory effects of vascular endothelial growth factor in the uterine circulation of the rat. Am. J. Obstet. Gynecol. 2000;183:449–453
  56. Torgersen KL, Curran CA. A systematic approach to the physiologic adaptations of pregnancy. Crit. Care Nurs. Q. 2006;29:2–19
  57. Tulchinsky D, Hobel JH, Yeager E, Marshall JR. Plasma estrone, estradiol, progesterone, and 17-hydroxyprogesterone in human pregnancy 1. Normal pregnancy. Am. J. Obstet. Gynecol. 1972;112:1095–1100
  58. Wartella J, Amory E, Macbeth AH, McNamara I, Stevens L, Madonia L, et al. Single or multiple reproductive experiences attenuate neurobehavioral stress and fear responses in the female rat. Physiol. Behav. 2003;79:373–381

PII: S0306-4530(10)00031-4

doi: 10.1016/j.psyneuen.2010.01.015

Psychoneuroendocrinology
Volume 35, Issue 8 , Pages 1148-1155 , September 2010