Psychoneuroendocrinology
Volume 35, Issue 8 , Pages 1178-1186 , September 2010

Parathyroid hormone-related protein has an anorexigenic activity via activation of hypothalamic urocortins 2 and 3

  • Akihiro Asakawa

      Affiliations

    • Department of Social and Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan
    • ,
  • Mineko Fujimiya

      Affiliations

    • Department of Anatomy, Sapporo Medical University, Sapporo 520-2192, Japan
    • ,
  • Akira Niijima

      Affiliations

    • Department of Physiology, Niigata University School of Medicine, Niigata 951-8510, Japan
    • ,
  • Kazunori Fujino

      Affiliations

    • Department of Surgery, Shiga University of Medical Science, Otsu 520-2192, Japan
    • ,
  • Noriko Kodama

      Affiliations

    • Department of Microbial Chemistry, Kobe Pharmaceutical University, Kobe 658-8558, Japan
    • ,
  • Yuki Sato

      Affiliations

    • Department of Bioorganic Chemistry, Hokuriku University, Kanazawa 920-1181, Japan
    • ,
  • Ikuo Kato

      Affiliations

    • Department of Bioorganic Chemistry, Hokuriku University, Kanazawa 920-1181, Japan
    • ,
  • Hiroaki Nanba

      Affiliations

    • Department of Microbial Chemistry, Kobe Pharmaceutical University, Kobe 658-8558, Japan
    • ,
  • Alessandro Laviano

      Affiliations

    • Department of Clinical Medicine, University La Sapienza, Rome 00185, Italy
    • ,
  • Michael M. Meguid

      Affiliations

    • Department of Surgery, Suny Upstate Medical University, NY 13210, USA
    • ,
  • Akio Inui

      Affiliations

    • Department of Social and Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 99 275 5751; fax: +81 99 275 5749.

Received 2 October 2009 ,Revised 18 January 2010 ,Accepted 2 February 2010.

References 

  1. Asakawa A, Inui A, Kaga T, Yuzuriha H, Nagata T, Ueno N, et al. Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin. Gastroenterology. 2001;120:337–345
  2. Bernstein IL, Goehler LE, Bouton ME. Relative potency of foods and drinks as targets in aversion conditioning. Behav. Neural. Biol. 1983;37:134–148
  3. Burtis WJ, Wu T, Bunch C, Wysolmerski JJ, Insogna KL, Weir EC, et al. Identification of a novel 17,000-dalton parathyroid hormone-like adenylate cyclase-stimulating protein from a tumor associated with humoral hypercalcemia of malignancy. J. Biol. Chem. 1987;262:7151–7156
  4. Burtis WJ, Brady TG, Orloff JJ, Ersbak JB, Warrell , Olson BR, et al. Immunochemical characterization of circulating parathyroid hormone-related protein in patients with humoral hypercalcemia of cancer. N. Engl. J. Med. 1990;322:1106–1112
  5. Chen CY, Inui A, Asakawa A, Fujino K, Kato I, Chen CC, et al. Des-acyl ghrelin acts by CRF type 2 receptors to disrupt fasted stomach motility in conscious rats. Gastroenterology. 2005;129:8–25
  6. Czimmer J, Million M, Tache Y. Urocortin 2 acts centrally to delay gastric emptying through sympathetic pathways while CRF and urocortin 1 inhibitory actions are vagal dependent in rats. Am. J. Physiol. 2006;290:G511–G518
  7. Dautzenberg FM, Hauger RL. The CRF peptide family and their receptors: yet more partners discovered. Trends Pharmacol. Sci. 2002;23:71–77
  8. Duggan JP, Booth DA. Obesity, overeating, and rapid gastric emptying in rats with ventromedial hypothalamic lesions. Science. 1986;231:609–611
  9. Flier JS, Maratos-Flier E. Obesity and the hypothalamus: novel peptides for new pathways. Cell. 1998;92:437–440
  10. Forero A, Lobuglio AF. History of antibody therapy for non-Hodgkin's lymphoma. Semin. Oncol. 2003;30:1–5
  11. Fujino K, Inui A, Asakawa A, Kihara N, Fujimura M, Fujimiya M. Ghrelin induces fasted motor activity of the gastrointestinal tract in conscious fed rats. J. Physiol. 2003;550:227–240
  12. Gaich G, Burtis WJ. Measurement of circulating parathyroid hormone-related protein in rats with humoral hypercalcemia of malignancy using a two-site immunoradiometric assay. Endocrinology. 1990;127:1444–1449
  13. Geary N, Le Sauter J, Noh U. Glucagon acts in the liver to control spontaneous meal size in rats. Am. J. Physiol. 1993;264:R116–R122
  14. Harvey KB, Bothe A, Blackburn GL. Nutritional assessment and patient outcome during oncological therapy. Cancer. 1979;43:2065–2069
  15. Hsu SY, Hsueh AJ. Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor. Nat. Med. 2001;7:605–611
  16. Iguchi H, Aramaki Y, Maruta S, Takiguchi S. Effects of anti-parathyroid hormone-related protein monoclonal antibody and osteoprotegerin on PTHrP-producing tumor-induced cachexia in nude mice. J. Bone Miner. Metab. 2006;24:16–19
  17. Inui A. Cancer anorexia-cachexia syndrome: current issues in research and management. C. A. Cancer J. Clin. 2002;52:72–91
  18. Inui A, Asakawa A, Bowers CY, Mantovani G, Laviano A, Meguid MM, et al. Ghrelin, appetite, and gastric motility: the emerging role of the stomach as an endocrine organ. FASEB J. 2004;18:439–456
  19. Karaplis AC, Luz A, Glowacki J, Bronson RT, Tybulewicz VL, Kronenberg HM, et al. Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene. Genes Dev. 1994;8:277–289
  20. Koda S, Date Y, Murakami N, Shimbara T, Hanada T, Toshinai K, et al. The role of the vagal nerve in peripheral PYY3-36-induced feeding reduction in rats. Endocrinology. 2005;146:2369–2375
  21. Moseley JM, Kubota M, Diefenbach-Jagger H, Wettenhall RE, Kemp BE, Suva LJ, et al. Parathyroid hormone-related protein purified from a human lung cancer cell line. Proc. Natl. Acad. Sci. U.S.A. 1987;84:5048–5052
  22. Niijima A, Meguid MM. An electrophysiological study on amino acid sensors in the hepato-portal system in the rat. Obes. Res. 1995;3:741S–745S
  23. Ohata H, Shibasaki T. Effects of urocortin 2 and 3 on motor activity and food intake in rats. Peptides. 2004;25:1703–1709
  24. Onuma E, Tsunenari T, Saito H, Sato K, Yamada-Okabe H, Ogata E. Parathyroid hormone-related protein (PTHrP) as a causative factor of cancer-associated wasting: possible involvement of PTHrP in the repression of locomotor activity in rats bearing human tumor xenografts. Int. J. Cancer. 2005;116:471–478
  25. Pardo FS, Lien WW, Fox HS, Efird JT, Aguilera JA, Burton DW, et al. Parathyroid hormone-related protein expression is correlated with clinical course in patients with glial tumors. Cancer. 2004;101:2622–2628
  26. Sato K, Onuma E, Yocum RC, Ogata E. Treatment of malignancy-associated hypercalcemia and cachexia with humanized anti-parathyroid hormone-related protein antibody. Semin. Oncol. 2003;30:167–173
  27. Schnell FM. Chemotherapy-induced nausea and vomiting: the importance of acute antiemetic control. The Oncologist. 2003;28:187–198
  28. Schwartz MW, Woods SC, Porte DDJ, Seeley RJ, Baskin DG. Central nervous system control of food intake. Nature. 2000;404:661–671
  29. Strewler GJ, Stern PH, Jacobs JW, Eveloff J, Klein RF, Leung SC, et al. Parathyroid hormonelike protein from human renal carcinoma cells. Structural and functional homology with parathyroid hormone. J. Clin. Invest. 1987;80:1803–1807
  30. Strewler GJ. The physiology of parathyroid hormone-related protein. N. Engl. J. Med. 2000;342:177–185
  31. Toomey D, Redmond P, Bouchier-Hayes D. Mechanisms mediating cancer cachexia. Cancer. 1995;76:2418–2426
  32. Vaughan J, Donaldson C, Bittencourt J, Perrin MH, Lewis K, Sutton S, et al. Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor. Nature. 1995;378:287–292
  33. Zhang JV, Ren PG, Avsian-Kretchmer O, Luo CW, Rauch R, Klein C, et al. Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake. Science. 2005;5750:996–999

PII: S0306-4530(10)00034-X

doi: 10.1016/j.psyneuen.2010.02.003

Psychoneuroendocrinology
Volume 35, Issue 8 , Pages 1178-1186 , September 2010

Article Tools

* Image Usage & Resolution