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Editorial Board
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CO2
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Neuroactive steroids: An update of their roles in central and peripheral nervous system
Summary: After five editions, the congress on “Steroids and Nervous System” held in Torino, Italy, represents an important international event for researchers involved in this field aimed to recapitul...
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Roberto Cosimo Melcangi,
Giancarlo Panzica
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S1-S8
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Modulation of steroid action in the central and peripheral nervous systems by nuclear receptor coactivators
Summary: Steroid hormones act in the central and peripheral nervous systems to regulate a variety of functions, including development, cell proliferation, cognition and behavior. Many of these effects...
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Marc J. Tetel
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S9-S19
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Importance of steroid receptor coactivators in the modulation of steroid action on brain and behavior
Summary: Steroid receptors such as estrogen and androgen receptors are nuclear receptors involved in the transcriptional regulation of a large number of target genes. Steroid-dependent protein express...
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Thierry D. Charlier
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S20-S29
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The selective estrogen receptor-alpha coactivator, RPL7, and sexual differentiation of the songbird brain
Summary: The brain and behavior of the Australian zebra finch (Taeniopygia guttata) are sexually dimorphic. Only males sing courtship songs and the regions of the brain involved in the learning and pr...
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Kelli A. Duncan,
Pedro Jimenez,
Laura L. Carruth
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S30-S38
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Corepressors, nuclear receptors, and epigenetic factors on DNA: A tail of repression
Summary: The differential exposure to circulating steroid hormones during brain development can have lasting consequences on brain function and behavior; therefore, the tight control of steroid hormon...
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Anthony P. Auger,
Heather M. Jessen
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S39-S47
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Neurosteroids: Endogenous allosteric modulators of GABAA receptors
Summary: In the mammalian central nervous system activation of the ionotropic GABAA receptor by the neurotransmitter GABA plays a crucial role in controlling neuronal excitability. This essential form...
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Jeremy J. Lambert,
Michelle A. Cooper,
Ross D.J. Simmons,
Cameron J. Weir,
Delia Belelli
et al.
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S48-S58
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The influence of the membrane on neurosteroid actions at GABAA receptors
Summary: Modern views of anesthetic neurosteroid interaction with the GABAA receptor conceptualize steroid ligands interacting with a protein binding site on the receptor. It has generally been assume...
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Gustav Akk,
Douglas F. Covey,
Alex S. Evers,
Joe Henry Steinbach,
Charles F. Zorumski,
Steven Mennerick
et al.
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S59-S66
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Function and modulation of δ-containing GABAA receptors
Summary: αβδ-Containing GABAA receptors are (1) localized to extra- and perisynaptic membranes, (2) exhibit a high sensitivity to GABA, (3) show little desensitization, and (4) are believed to be one ...
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Nadezhda N. Zheleznova,
Anna Sedelnikova,
David S. Weiss
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S67-S73
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Plasticity and function of extrasynaptic GABAA receptors during pregnancy and after delivery
Summary: Neuroactive steroids such as 3α-hydroxy-5α-pregnan-20-one (3α,5α-THP) are reduced metabolites of progesterone and are thought to play an important physiological role in local modulation of ne...
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Maria Cristina Mostallino,
Enrico Sanna,
Alessandra Concas,
Giovanni Biggio,
Paolo Follesa
et al.
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S74-S83
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Steroid hormone fluctuations and GABAAR plasticity
Summary: Conditions of changing steroid hormone levels are a particularly vulnerable time for the manifestation of neurological disorders, including catamenial epilepsy, premenstrual syndrome (PMS), a...
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Jamie Maguire,
Istvan Mody
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S84-S90
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Puberty, steroids and GABAA receptor plasticity
Summary: GABAA receptors (GABAR) mediate most inhibition in the CNS and are also a target for neuroactive steroids such as 3α,5[α]β-THP (3αOH-5[α]β-OH-pregnan-20-one or [allo]pregnanolone). Although t...
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Sheryl S. Smith,
Chiye Aoki,
Hui Shen
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S91-S103
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Action of estrogen on survival of basal forebrain cholinergic neurons: Promoting amelioration
Summary: Extensive studies during the past two decades provide compelling evidence that the gonadal steroid, estrogen, has the potential to affect the viability of basal forebrain cholinergic neurons....
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István M. Ábrahám,
Zsombor Kőszegi,
Emeline Tolod-Kemp,
Éva M. Szegő
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S104-S112
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Neuroprotective actions of selective estrogen receptor modulators
Summary: Decreasing levels of sex hormones with aging may have a negative impact on brain function, since this decrease is associated with the progression of neurodegenerative disorders, increased dep...
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Lydia L. DonCarlos,
Iñigo Azcoitia,
Luis M. Garcia-Segura
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S113-S122
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The opposing roles of estradiol on synaptic protein expression in hippocampal cultures
Summary: Estrogen-induced synaptic plasticity was frequently shown by an increase of spines at apical dendrites of CA1 pyramidal neurons after systemic application of estradiol to ovariectomized rats....
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Lars Fester,
Lepu Zhou,
Corinna Voets,
Christiana Ossig,
Erik Disteldorf,
Christian Peters,
Florian Bläute,
Janine Prange-Kiel,
Danuta Dudzinski,
Hubertus Jarry,
Gabriele M. Rune
et al.
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S123-S129
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Estradiol and the relationship between dendritic spines, NR2B containing NMDA receptors, and the magnitude of long-term potentiation at hippocampal CA3–CA1 synapses
Summary: When circulating estrogen levels decline as a natural consequence of menopause and aging in women, there is an increased incidence of deficits in working memory. In many cases, these deficits...
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Caroline C. Smith,
Lindsey C. Vedder,
Lori L. McMahon
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S130-S142
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Neurosteroids’ effects and mechanisms for social, cognitive, emotional, and physical functions
Summary: Hormones are trophic factors that integrate central and peripheral nervous system functions, and can influence social, cognitive, emotional and physical (SCEP) processes. Greater understandin...
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Cheryl A. Frye
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S143-S161
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Endocrine consequences of opioid therapy
Summary: Gonadal hormones are known to be affected by morphine and other opioids. In this paper, we summarize data collected in recent years which clearly indicate that the opioid-induced effects on s...
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Anna Maria Aloisi,
Caterina Aurilio,
Valeria Bachiocco,
Giovanni Biasi,
Paolo Fiorenzani,
Maria Caterina Pace,
Valentina Paci,
Gilberto Pari,
Giandomenico Passavanti,
Laura Ravaioli,
Gianfranco Sindaco,
Renato Vellucci,
Ilaria Ceccarelli
et al.
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S162-S168
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Evidence for a key role of steroids in the modulation of pain
Summary: Neurotransmitters such as glutamate, substance P, serotonin and gamma-aminobutyric acid pivotally control pain mechanisms. It is also well known that inflammatory and/or neuropathic pain may ...
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Ayikoe G. Mensah-Nyagan,
Laurence Meyer,
Véronique Schaeffer,
Cherkaouia Kibaly,
Christine Patte-Mensah
et al.
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S169-S177
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Are neuroactive steroids promising therapeutic agents in the management of acute and chronic pain?
Summary: Neuroactive steroids with potentiating effects on GABAA channels and inhibitory effects on T-type Ca2+ channels which are located in peripheral sensory neurons are potent modulators of pain p...
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Vesna Jevtovic-Todorovic,
Douglas F. Covey,
Slobodan M. Todorovic
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S178-S185
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The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders
Summary: FK506 binding protein 51 or FKBP5 is a co-chaperone of hsp90 which regulates glucocorticoid receptor (GR) sensitivity. When it is bound to the receptor complex, cortisol binds with lower affi...
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Elisabeth B. Binder
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S186-S195
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Neuropsychological functioning in health and mood disorder: Modulation by glucocorticoids and their receptors
Summary: Numerous studies have shown that disturbances in hypothalamic–pituitary–adrenal (HPA) axis function and consequent hypercortisolaemia occur in a significant proportion of patients with mood d...
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Peter Gallagher,
Keith S. Reid,
I. Nicol Ferrier
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S196-S207
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Neuronal plasticity: A link between stress and mood disorders
Summary: Although stress represents the major environmental element of susceptibility for mood disorders, the relationship between stress and disease remains to be fully established. In the present ar...
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Francesca Calabrese,
Raffaella Molteni,
Giorgio Racagni,
Marco A. Riva
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S208-S216
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Sex-dependent alterations in response to maternal deprivation in rats
Summary: We review here our latest results regarding short- and long-term effects of a neonatal maternal deprivation (MD) stress [24h at postnatal day (PND) 9] on diverse psychoneuroimmunoendocrine pa...
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M.P. Viveros,
R. Llorente,
M. López-Gallardo,
J. Suarez,
F. Bermúdez-Silva,
M. De la Fuente,
F. Rodriguez de Fonseca,
L.M. Garcia-Segura
et al.
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S217-S226
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Sex differences in the self-administration of cannabinoids and other drugs of abuse
Summary: Many studies have provided evidence for important sex-dependent differences in the origins, outcomes and treatment of drug abuse and dependence. Preclinical studies typically have employed an...
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Liana Fattore,
Paola Fadda,
Walter Fratta
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S227-S236
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Sex differences in the cannabinoid regulation of energy homeostasis
Summary: This review highlights the progress made thus far in characterizing the behavioral and cellular mechanisms through which cannabinoids regulate energy homeostasis. We performed microstructural...
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Borzoo Farhang,
Shanna Diaz,
Stephanie L. Tang,
Edward J. Wagner
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S237-S246
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Developmental vitamin D deficiency causes abnormal brain development
Summary: There is now clear evidence that vitamin D is involved in brain development. Our group is interested in environmental factors that shape brain development and how this may be relevant to neur...
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D.W. Eyles,
F. Feron,
X. Cui,
J.P. Kesby,
L.H. Harms,
P. Ko,
J.J. McGrath,
T.H.J. Burne
et al.
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S247-S257
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Transient prenatal vitamin D deficiency is associated with changes of synaptic plasticity in the dentate gyrus in adult rats
Summary: Transient prenatal vitamin D deficiency is considered a neurodevelopmental animal model in schizophrenia research. Vitamin D deficiency in female rats causes morphological, cellular and molec...
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Gisela Grecksch,
Heinz Rüthrich,
Volker Höllt,
Axel Becker
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S258-S264
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Vitamin D, a neuro-immunomodulator: Implications for neurodegenerative and autoimmune diseases
Summary: It has been known for more than 20 years that vitamin D exerts marked effects on immune and neural cells. These non-classical actions of vitamin D have recently gained a renewed attention sin...
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D.A. Fernandes de Abreu,
D. Eyles,
F. Féron
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S265-S277
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Vitamin D, nervous system and aging
Summary: This is a mini-review of vitamin D3, its active metabolites and their functioning in the central nervous system (CNS), especially in relation to nervous system pathologies and aging. The vita...
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P. Tuohimaa,
T. Keisala,
A. Minasyan,
J. Cachat,
A. Kalueff
et al.
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S278-S286
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